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1. WO2020196233 - COMPOSITION FOR PROMOTING CARTILAGE TISSUE REGENERATION

Publication Number WO/2020/196233
Publication Date 01.10.2020
International Application No. PCT/JP2020/012229
International Filing Date 19.03.2020
IPC
A61P 19/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 19/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
A61P 43/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 35/28 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
A61L 27/22 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
14Macromolecular materials
22Polypeptides or derivatives thereof
Applicants
  • 国立大学法人東京医科歯科大学 NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY [JP]/[JP]
Inventors
  • 辻 邦和 TSUJI Kunikazu
  • 尾島 美代子 OJIMA Miyoko
  • 宗田 大 MUNETA Takeshi
  • 古賀 英之 KOGA Hideyuki
  • 関矢 一郎 SEKIYA Ichiro
Agents
  • 特許業務法人セントクレスト国際特許事務所 CENTCREST IP ATTORNEYS
Priority Data
2019-05941826.03.2019JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) COMPOSITION FOR PROMOTING CARTILAGE TISSUE REGENERATION
(FR) COMPOSITION POUR FAVORISER LA RÉGÉNÉRATION DE TISSU CARTILAGINEUX
(JA) 軟骨組織の再生を促進するための組成物
Abstract
(EN)
In the present invention, it is revealed that activin has an activity of promoting regeneration of the meniscus or cartilage tissue and an activity of promoting growth of MSCs without affecting differentiation/pluripotency thereof. It is also discovered that, by using activin, it is possible to treat and prevent meniscal damage or cartilage disorders, including suppression of pain and cartilage degeneration.
(FR)
Dans la présente invention, il est révélé que l'activine a une activité favorisant la régénération du ménisque ou du tissu cartilagineux et une activité favorisant la croissance des MSC sans affecter leur différenciation/pluripotence. Il est également découvert que, en utilisant l'activine, il est possible de traiter et de prévenir des lésions du ménisque ou des troubles du cartilage, y compris la suppression de la douleur et de la dégénérescence du cartilage.
(JA)
アクチビンが、分化多能性に影響を与えることなく、MSCの増殖を促進する活性、半月板又は軟骨組織の再生を促進する活性を有することを明らかにした。さらに、アクチビンを用いることにより、軟骨の退行変性及び疼痛の抑制も含め、半月板損傷又は軟骨障害を治療及び予防することが可能となることも見出した。
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