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1. WO2020194563 - AGENT FOR PREVENTING OR IMPROVING SYMPTOMS OR DISEASE CAUSED BY PHENOLS

Publication Number WO/2020/194563
Publication Date 01.10.2020
International Application No. PCT/JP2019/013073
International Filing Date 27.03.2019
IPC
A61K 31/095 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
095Sulfur, selenium or tellurium compounds, e.g. thiols
A61K 31/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
A61K 31/192 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
192having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/198 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
A61K 31/352 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/47 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
Applicants
  • 国立大学法人東北大学 TOHOKU UNIVERSITY [JP]/[JP]
Inventors
  • 阿部 高明 ABE, Takaaki
  • 富岡 佳久 TOMIOKA, Yoshihisa
  • 松本 洋太郎 MATSUMOTO, Yotaro
  • 中山 亨 NAKAYAMA, Toru
Agents
  • 廣田 雅紀 HIROTA, Masanori
Priority Data
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) AGENT FOR PREVENTING OR IMPROVING SYMPTOMS OR DISEASE CAUSED BY PHENOLS
(FR) AGENT POUR PRÉVENIR OU AMÉLIORER DES SYMPTÔMES OU UNE MALADIE PROVOQUÉS PAR DES PHÉNOLS
(JA) フェノール類に起因する症状又は疾患の予防若しくは改善剤
Abstract
(EN)
The purpose of the present invention is to provide a substance which has the action of reducing phenols and which has the action of preventing or improving symptoms or disease caused by phenols. Because administration of the compound shown in formula (I) can effectively reduce phenols produced by tyrosine phenol lyase-expressing bacteria present in the organism and substances obtained through metabolism of said phenols in the organism, said compound is useful for preventing or improving symptoms or disease caused by phenols or metabolites thereof.
(FR)
Le but de la présente invention est de fournir une substance qui a l'action de réduire les phénols et qui a l'action de prévenir ou d'améliorer des symptômes ou une maladie provoqués par des phénols. Etant donné que l'administration du composé représenté dans la formule (I) peut réduire efficacement les phénols produits par les bactéries exprimant la tyrosine phénol-lyase présentes dans l'organisme et les substances obtenues par le métabolisme desdits phénols dans l'organisme, ledit composé est utile pour prévenir ou améliorer des symptômes ou une maladie provoqués par des phénols ou des métabolites de ceux-ci.
(JA)
本発明の課題は、フェノール類を低減する作用や、フェノール類に起因する症状又は疾患を予防若しくは改善する作用を有する物質を提供することにある。 以下の式(I)で示される化合物等を投与すると、生体中に存在するチロシンフェノールリアーゼ発現細菌から産生されるフェノールや、当該フェノールが生体中で代謝されることにより得られる物質を効果的に低減することができるため、フェノール又はその代謝物に起因する症状又は疾患の予防若しくは改善に有用である。
Latest bibliographic data on file with the International Bureau