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1. WO2020194311 - METHODS FOR MODIFYING TRANSLATION

Publication Number WO/2020/194311
Publication Date 01.10.2020
International Application No. PCT/IL2020/050367
International Filing Date 26.03.2020
IPC
C12N 15/67 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
67General methods for enhancing the expression
C12N 15/10 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
Applicants
  • RAMOT AT TEL-AVIV UNIVERSITY LTD. [IL]/[IL]
Inventors
  • TULLER, Tamir
  • BAHIRI, Shir
  • APT, Boaz
Agents
  • KESTEN, Dov
Priority Data
62/825,14328.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR MODIFYING TRANSLATION
(FR) PROCÉDÉS DE MODIFICATION DE LA TRADUCTION
Abstract
(EN)
Nucleic acid molecules comprising a mutation that mutation modulates the interaction strength of the nucleic acid molecule to a 16S ribosomal RNA are provided. Methods of improving the translation process of a nucleic acid molecule and producing a nucleic acid molecule optimized for translation, as well as cells comprising the nucleic acid molecules are also provided.
(FR)
L'invention concerne des molécules d'acides nucléiques comprenant une mutation, ladite mutation modulant la force d'interaction de la molécule d'acide nucléique avec un ARN ribosomal 16S. L'invention concerne également des procédés d'amélioration du processus de traduction d'une molécule d'acide nucléique et de production d'une molécule d'acide nucléique optimisée pour la traduction, ainsi que des cellules comprenant les molécules d'acides nucléiques.
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