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1. WO2020194063 - A LIVE AND ATTENUATED FLAVIVIRUS COMPRISING A MUTATED M PROTEIN

Publication Number WO/2020/194063
Publication Date 01.10.2020
International Application No. PCT/IB2020/000302
International Filing Date 27.03.2020
IPC
C12N 7/04 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
04Inactivation or attenuation; Producing viral sub-units
A61K 39/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
CPC
C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
C12N 2770/24122
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2770ssRNA Viruses positive-sense
00011ssRNA Viruses positive-sense
24011Flaviviridae
24111Flavivirus, e.g. yellow fever virus, dengue, JEV
24122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
C12N 2770/24134
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2770ssRNA Viruses positive-sense
00011ssRNA Viruses positive-sense
24011Flaviviridae
24111Flavivirus, e.g. yellow fever virus, dengue, JEV
24134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
C12N 2770/24162
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2770ssRNA Viruses positive-sense
00011ssRNA Viruses positive-sense
24011Flaviviridae
24111Flavivirus, e.g. yellow fever virus, dengue, JEV
24161Methods of inactivation or attenuation
24162by genetic engineering
C12N 2770/24171
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2770ssRNA Viruses positive-sense
00011ssRNA Viruses positive-sense
24011Flaviviridae
24111Flavivirus, e.g. yellow fever virus, dengue, JEV
24171Demonstrated in vivo effect
C12N 7/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
04Inactivation or attenuation; Producing viral sub-units
Applicants
  • INSTITUT PASTEUR [FR]/[FR]
  • UNIVERSITE DE PARIS [FR]/[FR]
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE [FR]/[FR]
Inventors
  • PARDIGON, Nathalie
  • BASSET, Justine
  • REY, Félix, Augusto
Agents
  • ERNEST GUTMANN - YVES PLASSERAUD SAS
Priority Data
62/825,73428.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A LIVE AND ATTENUATED FLAVIVIRUS COMPRISING A MUTATED M PROTEIN
(FR) FLAVIVURUS VIVANT ET ATTÉNUÉ COMPRENANT UNE PROTÉINE M MUTÉE
Abstract
(EN)
The application relates to the attenuation of a flavivirus, such as a West Nile Virus (WNV), Zika virus (ZIKV), Japanese Encephalitis Virus (JEV), Dengue Virus (DV), in particular DV4, or Usutu virus. The application notably provides a live and attenuated flavivirus, such as a live and attenuated WNV or ZIKV, comprising a mutated M protein. Said mutated M protein comprises or consists of a sequence, wherein at least the amino acids at positions 36 and 43 in said sequence are mutated. The application also provides embodiments deriving from said live and attenuated flavivirus, such as a WNV or ZIKV, such as nucleic acids, cells, cDNA clones, immunogenic compositions as well as uses and methods.
(FR)
L'invention concerne l'atténuation d'un flavivirus, tel qu'un virus du Nil occidental (WNO), un virus Zika (ZIKV), un virus de l'encéphalite Japonaise (JEV), un virus de la dengue (DV), en particulier un virus DV4, ou un virus Usutu unique. L'invention concerne notamment un flavivirus vivant et atténué, tel qu'un WNV vivant Et atténué ou ZIKV, comprenant une protéine M Mutée. Ladite protéine M mutée comprend ou est constituée d'une séquence, dans laquelle l'acide aminé à la position 36 est muté. Des moyens dérivés dudit VEJ vivant et atténué, tels que des acides nucléiques, des vecteurs d'expression, des cellules, des clones d'ADNc, des compositions immunogènes ainsi que leurs utilisations et des procédés sont en outre décrits.
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