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1. WO2020194046 - LOW-DOSE TRIPLE COMBINATION FORMULATION

Publication Number WO/2020/194046
Publication Date 01.10.2020
International Application No. PCT/IB2020/000141
International Filing Date 25.03.2020
IPC
A61K 31/4985 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A61K 31/64 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
64Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
A61K 31/155 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
155Amidines , e.g. guanidine , isourea , isothiourea
A61P 3/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
A61P 3/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 5/50 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5Drugs for disorders of the endocrine system
48of the pancreatic hormones
50for increasing or potentiating the activity of insulin
Applicants
  • THE GEORGE INSTITUTE FOR GLOBAL HEALTH [AU]/[AU]
Inventors
  • RODGERS, Anthony
  • MACMAHON, Stephen
Priority Data
62/823,57525.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) LOW-DOSE TRIPLE COMBINATION FORMULATION
(FR) PRÉPARATION À TRIPLE COMBINAISON À FAIBLE DOSE
Abstract
(EN)
Pharmaceutical compositions useful in the treatment of metabolic disorders including diabetes, the compositions comprising a) a dipeptidyl peptidase IV (DPP IV) inhibitor such as sitagliptin, b) a biguanide such as metformin, and c) a sulfonylurea such as glimepiride, wherein each one of the DPPIV inhibitor, biguanide and sulfonylurea are at a dose that is at about 20-75% of the lowest diabetes therapeutic dose (LDTD).
(FR)
L'invention concerne des compositions pharmaceutiques qui s'utilisent dans le traitement de troubles métaboliques comprenant le diabète, les compositions comportant a) un inhibiteur de la dipeptidyle peptidase IV (DPP IV) tel que la sitagliptine, b) un biguanide tel que la metformine, et c) une sulfonylurée telle que le glimépiride, chacun de ces élements, l'inhibiteur de DPPIV, le biguanide et la sulfonylurée, étant présents à une dose approximativement comprise entre 20 % et 75 % de la dose thérapeutique la plus faible pour le diabète (LDTD).
Latest bibliographic data on file with the International Bureau