Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020193978 - PEPTIDES AND USE THEREOF

Publication Number WO/2020/193978
Publication Date 01.10.2020
International Application No. PCT/GB2020/050804
International Filing Date 25.03.2020
IPC
C07K 7/64 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
64Cyclic peptides containing only normal peptide links
C12N 9/12 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides ; , e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 7/64
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
64Cyclic peptides containing only normal peptide links
C12N 9/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
C12Y 207/11022
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
207Transferases transferring phosphorus-containing groups (2.7)
11Protein-serine/threonine kinases (2.7.11)
11022Cyclin-dependent kinase (2.7.11.22)
Applicants
  • WARENIUS, Hilmar [GB]/[GB]
Inventors
  • WARENIUS, Hilmar
Agents
  • APPLEYARD LEES IP LLP
Priority Data
1904099.725.03.2019GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PEPTIDES AND USE THEREOF
(FR) PEPTIDES ET LEUR UTILISATION
Abstract
(EN)
The present invention relates to a cyclic peptide comprising an active region comprising the amino acid sequence X1X2X3X4X5X6 or a salt, derivative, prodrug or mimetic thereof. X2 and X5 are arginine; and either: X1 is (7-methoxy-coumarin-4-yl)-Ala-OH (Dac) and X3, X4 and X6 are any amino acid; or X3 is sarcosine (Sar) and X1, X4 and X6 are any amino acid; or X4 is 5,5-dimethylproline (dm Pro) or 3-amino-3-(2-naphthyl)propionic acid (Nap) and X1, X3 and X6 are any amino acid; or X6 is Nap and X1, X3 and X4 are any amino acid. The present invention further relates to a pharmaceutical composition comprising the cyclic peptide and the peptide for use in medicine, and particularly cancer.
(FR)
La présente invention concerne un peptide cyclique comprenant une région active comprenant la séquence d'acides aminés X1X2X3X4X5X6 ou un sel, un dérivé, un promédicament ou un mimétique de celui-ci. X2 et X5 représentent l'arginine; et soit X1 représente le (7-méthoxy-coumarine-4-yl)-Ala-OH (Dac) et X3, X44 et X6 représentent n'importe quel acide aminé; soit X3 représente la sarcosine (Sar) et X1, X4 et X6 représentent n'importe quel acide aminé; soit X4 représente la 5,5-diméthylproline (dm Pro) ou l'acide 3-amino-3-(2-naphtyl) propionique (Nap) et X1, X3 et X6 représentent n'importe quel acide aminé; soit X6 représente le Nap et X1, X3 et X4 représentent n'importe quel acide aminé. La présente invention concerne en outre une composition pharmaceutique comprenant le peptide cyclique et le peptide pour une utilisation en médecine et, en particulier, contre le cancer.
Latest bibliographic data on file with the International Bureau