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1. WO2020193802 - POLYMERIC CONJUGATES AND USES THEREOF

Publication Number WO/2020/193802
Publication Date 01.10.2020
International Application No. PCT/EP2020/058940
International Filing Date 30.03.2020
IPC
A61K 47/64 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61P 25/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 47/645
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
645Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • FUNDACIÓN DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE [ES]/[ES]
  • FUNDACIÓN STEP BY STEP [ES]/[ES]
Inventors
  • MORENO MANZANO, Victoria
  • GIRALDO REBOLOSO, Esther
  • REQUEJO AGUILAR, Raquel
  • ALASTRUE AGUDO, Ana
  • VICENT DOCÓN, María Jesús
  • ARMIÑAN DE BENITO, Ana
  • ARROYO-CRESPO, Juan José
  • NEBOT CARDÁ, Vicent Josep
  • ZAGORODKO, Oleksandr
  • DORDEVIC, Snezana
Agents
  • ABG INTELLECTUAL PROPERTY LAW, S.L.
Priority Data
19382225.128.03.2019EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) POLYMERIC CONJUGATES AND USES THEREOF
(FR) CONJUGUÉS POLYMÈRES ET LEURS UTILISATIONS
Abstract
(EN)
The present invention relates to novel chemical entities comprising a polymeric carrier incorporating covalently linked drug(s) as well as their pharmaceutical compositions containing the said polymer-drug conjugates as pharmaceutical agents and their uses thereof in therapy and, more particularly, but not exclusively, to novel conjugates having attached thereto a targeting moiety, an imaging agent and one or more therapeutic agents to promote axonal growth and for the treatment of neurodegenerative and inflammatory diseases, central nervous system traumatic injuries and cancer.
(FR)
La présente invention concerne de nouvelles entités chimiques comprenant un support polymère incorporant un ou des médicament(s) lié(s) de manière covalente ainsi que leurs compositions pharmaceutiques contenant lesdits conjugués polymère-médicament en tant qu'agents pharmaceutiques et leurs utilisations en thérapie et, plus particulièrement, mais pas exclusivement, de nouveaux conjugués ayant fixé à celui-ci une fraction de ciblage, un agent d'imagerie et un ou plusieurs agents thérapeutiques pour favoriser la croissance axonale et pour le traitement de maladies neurodégénératives et inflammatoires, de lésions traumatiques du système nerveux central et du cancer.
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