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1. WO2020193752 - USE OF GREEN COFFEE BASED COMPOSITIONS FOR IMPROVING INSULIN PROFILE

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[ EN ]

Claims

1 . A green coffee-based composition comprising esterase treated decaffeinated green coffee extract (HDGCE) for use in the treatment or prevention of a disorder linked to an increase in plasma postprandial insulin in a subject wherein the subject is administered an effective dose of esterase treated decaffeinated green coffee extract with an amount of 40-200 mg/day.

2. The green-coffee based composition comprising esterase treated decaffeinated green coffee extract (HDGCE) for use according to claim 1, wherein the rate of uptake of glucose by skeletal muscle cells is increased in a subject.

3. The green-coffee based composition comprising esterase treated decaffeinated green coffee extract (HDGCE) for use according to claim 1, wherein the pancreatic beta cell sensitivity to glucose is improved in a subject.

4. The composition for use according to claims 1 to 3 wherein the disorder is selected from the group consisting of diabetes, for example gestational diabetes; impairment of glucose metabolism; hyperinsulinemia or insulin resistance.

5. The composition for use according to claims 1 to 4 wherein the subject is a diabetic or pre-diabetic patient.

6. The composition for use according to any one of claims 1 to 5 wherein the composition is a liquid beverage composition or powder or snack bar.

7. The composition for use according to claim 6 wherein the total content of caffeic acid and ferulic acid is between 10 and 60 mg and the composition may be a heat-treated composition.

8. The composition for use according to claim 7 wherein the ratio of caffeic acidTerulic acid is at least greater than 2: 1.

9. The composition for use according to claim 8 wherein the ratio of caffeic acid:ferulic acid ranges from 3: 1 to 10: 1.

10. The composition of any one of the claims 1 to 9, wherein the said subject, in addition to the administration of HDGCE is further complemented with a meal of at least 200 kcal.

1 1 . The composition of any one of the claims 1 to 10, wherein the said subject is human.

12. A process for preparing the composition of any one of the claims 1 to 11, comprising the steps of:

(i) Preparing a decaffeinated green coffee extract by contacting green coffee beans with water, steam, organic solvent, super critical CO2 and/or mixtures thereof;

(ii) Optionally drying the decaffeinated green coffee extract;

(iii) Contacting the obtained decaffeinated green coffee extract with esterase enzyme, at pH ranging from 4 to 7 and temperature ranging from 20 to 50°C for incubation time ranging from 1 to 6 hours;

(iv) Heating the above enzyme treated green coffee extract from temperature ranging from 80 to 120°C for 1 to 30 minutes to deactivate the enzyme and to pasteurize the extract; and

(v) Optionally drying the extract to obtain the esterase treated decaffeinated green coffee extract (HDGCE).

13. A process of claim 12, wherein the drying step (ii) is spray or freeze drying.

14. The process of claims 12 and 13, wherein the esterase enzyme is chlorogenate exterase in a concentration ranging from 1 to 20 U/200mg of green coffee extract W/W dissolved in 1 ml of water or buffer.