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1. WO2020193693 - MEDICAL USES FOR BENZODIAZEPINES WITH A PARTICULAR EEG PATTERN

Publication Number WO/2020/193693
Publication Date 01.10.2020
International Application No. PCT/EP2020/058508
International Filing Date 26.03.2020
IPC
A61K 31/4468 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
4468having a nitrogen atom directly attached in position 4, e.g. clebopride, fentanyl
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 31/5517 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
551having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
55131,4-Benzodiazepines, e.g. diazepam
5517condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
A61K 45/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 23/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
23Anaesthetics
CPC
A61K 31/5517
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
551having two nitrogen atoms, e.g. dilazep
55131,4-Benzodiazepines, e.g. diazepam ; or clozapine
5517condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 9/0019
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
A61K 9/0043
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0043Nose
A61K 9/007
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
007Pulmonary tract; Aromatherapy
A61P 23/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
23Anaesthetics
Applicants
  • PAION UK LIMITED [GB]/[GB]
Inventors
  • BECK, Jürgen
  • SÖHNGEN, Wolfgang
  • SCHIPPERS, Frank
  • SCHÜTTLER, Jürgen
Agents
  • ROTH, Carla
  • KÖNIG, Gregor
  • TILMANN, Max W.
  • VON RENESSE, Dorothea
  • SZYNKA, Dirk
  • SMORODIN, Tobias
  • HEMSATH, Lars
  • LÜCKE, Robert
  • VERHASSELT, Jörn
  • HERTZSCH, Claudia
  • BENIK, Victoria
Priority Data
19165517.427.03.2019EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MEDICAL USES FOR BENZODIAZEPINES WITH A PARTICULAR EEG PATTERN
(FR) UTILISATIONS MÉDICALES DE BENZODIAZÉPINES AVEC UN MOTIF D'ÉLECTROENCÉPHALOGRAMME PARTICULIER
Abstract
(EN)
The present invention relates to a benzodiazepine or pharmaceutically acceptable salt thereof for use in inducing and/or maintaining a MOAA/S score of ≤ 1 in a human patient selected from an infant, a child and a patient with a cognitive impairment that is at least mild cognitive impairment, or for use in inducing and/or maintaining a MOAA/S score of ≤ 1 in a patient without causing brain damage, wherein the benzodiazepine or salt is defined by having the property of leading to one or more particular characteristics of an electroencephalogram of a human reference subject in case said benzodiazepine or salt is administered to said reference subject to induce and/or maintain a MOAA/S score of ≤ 1.
(FR)
La présente invention concerne une benzodiazépine ou un sel pharmaceutiquement acceptable de celle-ci pour une utilisation dans l'induction et/ou le maintien d'un score MOAA/S de ≤ 1 chez un patient humain sélectionné parmi un nourrisson, un enfant et un patient présentant un trouble cognitif qui est au moins un trouble cognitif léger, ou pour une utilisation dans l'induction et/ou le maintien d'un score MOAA/S de ≤ 1 chez un patient sans provoquer de lésion cérébrale, la benzodiazépine ou le sel étant défini en ayant la propriété de conduire à une ou plusieurs caractéristiques particulières de l'électroencéphalogramme d'un sujet humain de référence dans le cas où ladite benzodiazépine ou ledit sel est administré audit sujet de référence pour induire et/ou maintenir un score MOAA/S de ≤ 1.
Also published as
Latest bibliographic data on file with the International Bureau