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1. WO2020193660 - IMIDAZOLONYLQUINOLINE COMPOUNDS AND THERAPEUTIC USES THEREOF

Publication Number WO/2020/193660
Publication Date 01.10.2020
International Application No. PCT/EP2020/058425
International Filing Date 25.03.2020
IPC
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 31/4375 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
4375the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • MERCK PATENT GMBH [DE]/[DE]
Inventors
  • FUCHSS, Thomas
  • BECKER, Axel
  • KUBAS, Holger
  • GRAEDLER, Ulrich
Priority Data
19165664.427.03.2019EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMIDAZOLONYLQUINOLINE COMPOUNDS AND THERAPEUTIC USES THEREOF
(FR) COMPOSÉS D'IMIDAZOLONYLQUINOLINE ET LEURS UTILISATIONS THÉRAPEUTIQUES
Abstract
(EN)
The present invention relates to atropisomers, solid forms, salt forms and deuterated derivatives of the ATM inhibitor 8-(1,3-Dimethyl-1H-pyrazol-4-yl)-1-(3-fluoro-5-methoxy- pyridin-4-yl)-7-methoxy-3-methyl-1,3-dihydroimidazo[4,5-c]quinolin-2-one as well as compositions thereof. The stable atropisomers do not interconvert and are represented by the following formulae: Compound1, Compound2
(FR)
La présente invention concerne des atropisomères, des formes solides, des formes salines et des dérivés deutérés de l'inhibiteur ATM 8-(1,3-diméthyl-1H-pyrazol-4-yl)-1-(3-fluoro-5-méthoxy-pyridin-4-yl)-7-méthoxy-3-méthyl-1,3-dihydroimidazo[4,5-c]quinolin-2-one, ainsi que des compositions de ceux-ci. Les atropisomères stables ne s'interconvertissent pas et sont représentés par les formules suivantes : composé 1, composé 2.
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