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1. WO2020193613 - A BIOREACTOR SYSTEM

Publication Number WO/2020/193613
Publication Date 01.10.2020
International Application No. PCT/EP2020/058313
International Filing Date 25.03.2020
IPC
B01D 21/26 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
21Separation of suspended solid particles from liquids by sedimentation
26Separation of sediment aided by centrifugal force
B04C 5/103 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
CAPPARATUS USING FREE VORTEX FLOW, e.g. CYCLONES
5Apparatus in which the axial direction of the vortex is reversed
08Vortex chamber constructions
103Bodies or members, e.g. bulkheads, guides, in the vortex chamber
B04C 5/14 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
CAPPARATUS USING FREE VORTEX FLOW, e.g. CYCLONES
5Apparatus in which the axial direction of the vortex is reversed
14Construction of the underflow ducting; Apex constructions; Discharge arrangements
C12M 1/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
C12M 1/26 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
26Inoculator or sampler
CPC
B01D 21/265
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
21Separation of suspended solid particles from liquids by sedimentation
26Separation of sediment aided by centrifugal force ; or centripetal force
265by using a vortex inducer or vortex guide, e.g. coil
B04C 5/103
BPERFORMING OPERATIONS; TRANSPORTING
04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
CAPPARATUS USING FREE VORTEX FLOW, e.g. CYCLONES
5Apparatus in which the axial direction of the vortex is reversed
08Vortex chamber constructions
103Bodies or members, e.g. bulkheads, guides, in the vortex chamber
B04C 5/14
BPERFORMING OPERATIONS; TRANSPORTING
04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
CAPPARATUS USING FREE VORTEX FLOW, e.g. CYCLONES
5Apparatus in which the axial direction of the vortex is reversed
14Construction of the underflow ducting; Apex constructions; Discharge arrangements ; ; discharge through sidewall provided with a few slits or perforations
C12M 29/16
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
29Means for introduction, extraction or recirculation of materials, e.g. pumps
16Hollow fibers
C12M 29/18
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
29Means for introduction, extraction or recirculation of materials, e.g. pumps
18External loop; Means for reintroduction of fermented biomass or liquid percolate
C12M 33/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
33Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
10by centrifugation
Applicants
  • CYTIVA SWEDEN AB [SE]/[SE]
Inventors
  • CASTAN, Andreas
  • MEDRONHO, Ricardo, A
  • CASTILHO, Leda
  • WALTER BETTINARDI, Iona
Agents
  • LARSSON, Anders
  • ALDENBACK, Ulla
  • SORBY, Lennart
  • CAVILL, Ross
  • O'BRIEN, Dominic
Priority Data
1904083.125.03.2019GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A BIOREACTOR SYSTEM
(FR) SYSTÈME DE BIORÉACTEUR
Abstract
(EN)
A bioreactor system for culturing cells, comprising: - at least one bioreactor (3); and - at least one hydrocyclone (5a; 5b; 5c; 5d, 5d'; 5e) comprising: - a cell culture inlet (7) which is connected to a cell culture outlet (9) of the bioreactor (3) via a pump (11), whereby a cell culture from the bioreactor can be transferred to the hydrocyclone (5a; 5b; 5c; 5d, 5d'; 5e) when a cell culture is provided in the bioreactor; - a hydrocyclone separation part (13) into which cell culture can be introduced from the cell culture inlet (7), - a top outlet (15) through which a part of the cell culture with decreased cell concentration can be transferred after separation in the hydrocyclone separation part (13); and - a bottom outlet (17) through which a part of the cell culture with increased cell concentration can be transferred after separation in the hydrocyclone separation part (13), wherein said bottom outlet (17) of the hydrocyclone (5a; 5b; 5c; 5d, 5d'; 5e) is provided in a position such that when the bioreactor system is used for culturing cells the bottom outlet (17) is in connection with a headspace (21) of the bioreactor (3) and wherein said bottom outlet (17) is provided such that the bottom outlet (17) has a free space around it such that a cell culture transferred out form the bottom outlet (17) is allowed to freely discharge around the bottom outlet.
(FR)
L'invention concerne un système de bioréacteur pour la culture cellulaire, comprenant : Au moins un bioréacteur (3); et au moins un hydrocyclone (5a; 5b; 5c; 5d, 5d'; 5e) comprenant : - Une entrée de culture cellulaire (7) qui est reliée à une sortie de culture cellulaire (9) du bioréacteur (3) par l'intermédiaire d'une pompe (11), une culture cellulaire provenant du bioréacteur pouvant être transférée à l'hydrocyclone (5a; 5b; 5c; 5d, 5d'; 5e) lorsqu'une culture cellulaire est disposée dans le bioréacteur;-une partie de séparation hydrocyclone (13) dans laquelle une culture cellulaire peut être introduite à partir de l'entrée de culture cellulaire (7), - une sortie supérieure (15) à travers laquelle une partie de la culture cellulaire ayant une concentration cellulaire réduite peut être transférée après séparation dans la partie de séparation hydrocyclone (13); et - une sortie inférieure (17) à travers laquelle une partie de la culture cellulaire ayant une concentration cellulaire accrue peut être transférée après séparation dans la partie de séparation hydrocyclone (13), ladite sortie inférieure (17) de l'hydrocyclone (5a; 5b; 5c; 5d, 5d'; 5e) est disposée dans une position telle que lorsque le système de bioréacteur est utilisé pour la culture de cellules, la sortie inférieure (17) est en liaison avec un espace de tête (21) du bioréacteur (3) et ladite sortie inférieure (17) étant disposée de telle sorte que la sortie inférieure (17) a un espace libre autour de celui-ci de telle sorte qu'une culture cellulaire transférée à partir de la sortie inférieure (17) est autorisée à se décharger librement autour de la sortie inférieure.
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