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1. WO2020193468 - AUTO INJECTOR WITH BI-STABLE CLUTCH PLATE

Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

[ EN ]

Claims

1. An auto injector (100) for delivery of a medicament to a patient, the auto

injector (100) extending from a proximal end (102) to a distal end (104), wherein the auto injector (100) is adapted for receiving a cartridge assembly (200) supporting a syringe (300) comprising:

o a syringe compartment (302) containing the medicament;

o a hollow needle (304) through which the medicament can be delivered to a patient;

o a stopper (306) proximally movable inside the syringe compartment (302) for evacuating the medicament in the syringe compartment (302); o a syringe cap (308) adapted for protecting the needle (304); wherein the auto injector (100) comprises:

- a housing (110);

- a plunger (120) movably positioned inside the housing (110), the

plunger (120) being adapted for moving the stopper (306) inside the syringe compartment (302) proximally for delivery of the medicament;

- a plunger spring (140) adapted for moving the plunger (120) proximally for delivery of the medicament;

- a clutch assembly (150) position inside the housing (110), the clutch assembly (150) comprising a bi-stable clutch plate (170) comprising a flexible ring part (172) from where one or more retention arms (174) extend, the flexible ring part (172) being movable between:

• a first stable position where the one or more retention arms (174) protrudes outwardly and engages with an inside surface

(116) of the housing (110), wherein the flexible ring part (172) is in the first stable position during delivery of medicament, and

• a second stable position where the one or more retention arms (174) protrudes inwardly and are disengaged from the inside surface (116) of the housing (110),

wherein upon translation of the cartridge assembly (200) into the auto injector (100) after delivery of the medicament, the clutch plate retention arms (174) are brought into contact with release ribs (119) inside the housing (100) whereby the flexible ring part (172) on the clutch plate (170) is moved from the first stable position to the second stable position allowing the cartridge assembly (200) to be removed and the auto injector to be reset.

2. The auto injector (100) according to claim 1 , wherein the clutch assembly comprises:

- a clutch release sleeve (180) comprising a ring shaped part (182) with a distal surface (184) from where release sleeve arms (186) extends; and

- a clutch lock ring (160) comprising a first proximal clutch lock ring surface (166), and a second proximal clutch lock ring surface (164), wherein the distal surface (184) of the clutch release sleeve (180) are adapted for abutting the first proximal clutch lock ring surface (166) in a first position and the second proximal clutch lock ring surface (164) in a second position.

3. The auto injector (100) according to any preceding claim, wherein the clutch plate (170) is in the first stable position when the cartridge assembly (200) and the auto injector (100) are moved towards each other, and wherein the one or more retention arms (174) engaging the inside surface (116) of the housing (110) are ensuring that a spring pressure is held by the clutch plate (170) preventing movement of the clutch assembly within the housing, should the relative movement between the cartridge assembly (200) and the auto injector (100) towards each other stop.

4. The auto injector (100) according to any preceding claim, wherein the auto injector further comprises a housing collar (130) positioned at the proximal end (112) of the housing (110) partly extending inside the housing (110), wherein the housing collar (130) comprises a housing collar retention shelf (136) at its distal end, the housing collar retention shelf (136) being adapted for locking the cartridge assembly (200) to the auto injector (100) when the cartridge assembly (200) is fully inserted into the auto injector (100).

5. The auto injector (100) according to any preceding claim, wherein the clutch assembly (150) further comprises a clutch retainer (154) positioned between the clutch plate (170) and the cartridge assembly (200) when the cartridge assembly (200) is contained in the auto injector (100).

6. The auto injector (100) according to any preceding claim, wherein the plunger spring (140) is contained inside an inner plunger tube part (126).

7. The auto injector (100) according to any preceding claim, wherein the auto injector (100) further comprises a plunger spring pin (142) connected to the housing (110) and extending inside the inner plunger (120) tube part, wherein the plunger spring (140) is surrounding the plunger spring pin (142).

8. The auto injector (100) according to any preceding claim, wherein the auto injector (100) is adapted for receiving a cartridge assembly (200) into the proximal end (102) of the auto injector (100).

9. The auto injector (100) according to any preceding claim, wherein when the cartridge assembly (200) and the auto injector (100) are moved towards each other, the clutch assembly (150) and the plunger (120) are moved in the distal direction relative to the housing (110) whereby the plunger spring (140) is compressed.

10. The auto injector (100) according to any of the preceding claims 2-9, wherein the release sleeve arms (186) on the release sleeve (180) are further pressing against a proximal plunger surface (121) of the plunger (120) in a first position.

11. The auto injector (100) according to any of the preceding claims 2-10, wherein the clutch lock ring (160) is movable in the distal direction relatively to the release sleeve (180) upon movement of the cartridge assembly (200) distally within the auto injector (100).

12. The auto injector (100) according to any of the preceding claims 2-11 , wherein the release sleeve arms (186) of the clutch release sleeve (180) are adapted

for flexing inward upon disengagement of the clutch lock ring (160) from the release sleeve (180).

13. The auto injector (100) according to claim 12, wherein the release sleeve arms (186) are adapted for being secured in a locking opening (228) in the cartridge assembly (200) when flexing inward thereby locking the cartridge assembly (200) and the release sleeve (180) together.

14. The auto injector (100) according to claim 12 or 13, wherein when the release sleeve arms (186) of the clutch release sleeve (180) flex inward, the plunger

(120) is released thereby enabling the plunger spring (142) to move the plunger (120) proximally for delivery of the medicament.

15. The auto injector (100) according to any of the preceding claims 2-14 further comprising:

- a clutch cap (190) comprising a first proximal clutch cap surface (192) abutting the distal surface (184) on the ring shaped part (182) of the clutch release sleeve (180); and

- a clutch reset spring (152) positioned inside the clutch cap (190)

exerting a pressure on the clutch cap (190) and the clutch lock ring

(160).

16. The auto injector (100) according to claim 15, wherein the clutch lock ring (160) is adapted for compressing the clutch reset spring (152) when the lock ring (160) is moved in the distal direction upon movement of the cartridge assembly (200) for delivery of the medicament.

17. The auto injector (100) according to claim 16, wherein the clutch reset spring (152) is adapted for pushing the clutch lock ring (160) towards the release sleeve arms (186) after removal of the used cartridge assembly (200).

18. An auto injector system comprising an auto injector (100) according to any of the claims 1-17 and a cartridge assembly (200) for use in the auto injector (100), wherein the cartridge assembly (200) is adapted for supporting a syringe (300) comprising:

o a syringe compartment (302) containing the medicament;

o a hollow needle (304) through which the medicament can be delivered to a patient;

o a stopper (306) proximally movable inside the syringe compartment (302) for evacuating the medicament in the syringe compartment (302); o a syringe cap (308) adapted for protecting the needle (304); wherein the cartridge assembly (200) comprises:

- a needle shroud (210) comprising a hollow elongated tubular section (212) adapted for receiving the syringe (300); and

- a lock tube (220) extending around the tubular section (212) of the needle shroud (210), the lock tube (220) comprising a snap fit connection (222) adapted for securing the syringe (300) inside the lock tube (220) and the needle shroud (210).

19. The auto injector system according to claim 18, wherein the distal end (225) of the lock tube (220) comprises inwardly extending flanges (223), which locks the syringe (300) inside the lock tube (220) with the snap fit connection (222).

20. The auto injector system according to any of the claims 18-19, wherein the cartridge assembly (200) further comprises a cartridge assembly cap (240) and a grip tube (250), wherein the grip tube (250) is positioned inside the cartridge assembly cap (240), and wherein the grip tube (250) is adapted for capturing the syringe cap (308) when the syringe (300) is positioned inside the cartridge assembly (200).

21. The auto injector system according to claim 20, wherein the cartridge

assembly cap (240) comprises distally protruding tabs (242) abutting a proximal end (226) of the lock tube (220) thereby preventing proximal movement of the lock tube (220) relative to the needle shroud (210) when the cartridge assembly cap (240) is connected with the needle shroud (210).

22. The auto injector system according to any of the claims 20-21 , wherein the cartridge assembly cap (240) and the grip tube (250) are removable from the cartridge assembly (200) after the cartridge assembly (200) is fully inserted into the auto injector (100).

23. The auto injector system according to claim 22, wherein the needle shroud (210) is enabled for retracting into the housing (110) when removing the cartridge assembly cap (240).

24. The auto injector system according to claim 23, wherein depression of the housing (110) proximally towards the needle shroud (210) after removal of the cartridge assembly cap (240) retracts the needle shroud (210) into the housing (110).

25. The auto injector system according to any of the claims 18-24, wherein the lock tube (220) comprises one or more retention snaps (221) engaging on the housing collar retention shelf (136) securing the lock tube (220) inside the auto injector (100).

26. The auto injector system according to claim 25, wherein upon depression of the housing (110), the lock tube (220) comprising the syringe (300) is adapted for moving proximally together with the housing (110) enabling insertion of the needle (304).

27. The auto injector system according to claim 26, wherein the needle shroud

(210) is adapted for translating distally into the housing (110) when the housing (110) is depressed.

28. The auto injector system according to claim 27, wherein the lock tube (220) is adapted for at least partially rotating relatively to the housing (110) as the needle shroud (210) translates distally into the housing (110).

29. The auto injector system according to claim 28, wherein after release of

plunger (120), the lock tube (220) is adapted for completing the rotation

relatively to the housing (110) whereby the one or more lock tube retention snaps (221) are moved to a position allowing removal of the cartridge assembly (200) from the auto injector (100).

30. The auto injector system according to any of the claims 26-29, wherein upon depression of the housing (110), the needle shroud (210) is adapted for rotating the lock tube (220) relatively to the housing (110).

31. The auto injector system according to any of the claims 18-30, wherein the lock tube (220) comprises a lock tube channel (230) and the needle shroud

(210) comprises a needle shroud protrusion (216) movable inside the lock tube channel (230) between:

- a first lock tube channel position (231),

- a second lock tube channel position (232), and

- a third lock tube channel position (233).

32. The auto injector system according to claim 31 , wherein the needle shroud protrusion (216) is in the first lock tube channel position (231) before removal of the cartridge assembly cap (240).

33. The auto injector system according to any of the claims 31-32, wherein the needle shroud protrusion (216) is moved from the first lock tube channel position (231) to the second lock tube channel position (232) upon depression of the housing (110) after removal of the cartridge assembly cap (240).

34. The auto injector system according any of the claims 18-33, wherein the

cartridge assembly (200) further comprises a lock tube spring (202) positioned between a peripheral distal needle shroud support surface (214) and a proximal lock tube support surface (227).

35. The auto injector system according to claim 34, wherein the lock tube spring (202) is adapted for being compressed during delivery of the medicament, and for moving the needle shroud protrusion (216) from the second lock tube

channel position (232) to the third lock tube channel position (233) after delivery of the medicament decompresses.

36. The auto injector system according to claim 35, wherein when the needle shroud protrusion (216) is in the third lock tube channel position (233) compression of the needle shroud relative to the lock tube (220) is limited.

37. The auto injector system according to any of the claims 34-36, wherein the needle shroud (210) comprises a ring protrusion (213) whereon the distal needle shroud support surface (214) is, and whereon the needle shroud protrusion (216) is positioned.