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1. WO2020193431 - NOVEL INHIBITORS OF HISTONE DEACETYLASE 10

Publication Number WO/2020/193431
Publication Date 01.10.2020
International Application No. PCT/EP2020/057867
International Filing Date 20.03.2020
IPC
C07C 259/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
259Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
04without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
06having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • DEUTSCHES KREBSFORSCHUNGSZENTRUM [DE]/[DE]
Inventors
  • MILLER, Aubry
  • STEIMBACH, Raphael
  • GÉRALDY, Magalie
Agents
  • WALLINGER RICKER SCHLOTTER TOSTMANN
Priority Data
19164703.122.03.2019EP
19164715.522.03.2019EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL INHIBITORS OF HISTONE DEACETYLASE 10
(FR) NOUVEAUX INHIBITEURS DE L'HISTONE DÉSACÉTYLASE 10
Abstract
(EN)
The present invention relates to novel inhibitors of histone deacetylase 10 (HDAC10), novel pharmaceutical compositions comprising such inhibitors, and to novel methods of treating diseases, such as cancer, autoimmune disorders or neurodegeneration, using such novel inhibitors or methods of using such novel inhibitors in organ transplantation.
(FR)
La présente invention concerne de nouveaux inhibiteurs de l'histone désacétylase 10 (HDAC10), de nouvelles compositions pharmaceutiques comprenant de tels inhibiteurs, et de nouvelles méthodes de traitement de maladies, tels que le cancer, les troubles auto-immuns ou la neurodégénérescence, à l'aide de ces nouveaux inhibiteurs ou des procédés d'utilisation de ces nouveaux inhibiteurs dans une transplantation d'organe.
Also published as
Latest bibliographic data on file with the International Bureau