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1. WO2020193316 - HIGH AFFINITY ANTICALINS DIRECTED AGAINST HUMAN CD98HC

Publication Number WO/2020/193316
Publication Date 01.10.2020
International Application No. PCT/EP2020/057469
International Filing Date 18.03.2020
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
C07K 16/2896
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2896against molecules with a "CD"-designation, not provided for elsewhere
C07K 2317/34
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
C07K 2317/76
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
70characterized by effect upon binding to a cell or to an antigen
76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
C07K 2317/92
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
90characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
C07K 2317/94
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
90characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
94Stability, e.g. half-life, pH, temperature or enzyme-resistance
Applicants
  • TECHNISCHE UNIVERSITÄT MÜNCHEN [DE]/[DE]
Inventors
  • SKERRA, Arne
  • DEUSCHLE, Friedrich-Christian
  • SCHIEFNER, André
  • MORATH, Volker
Agents
  • VOSSIUS & PARTNER (No 31)
Priority Data
19165966.328.03.2019EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HIGH AFFINITY ANTICALINS DIRECTED AGAINST HUMAN CD98HC
(FR) ANTICALINS À HAUTE AFFINITÉ DIRIGÉS CONTRE LE CD98HC HUMAIN
Abstract
(EN)
The present invention relates to a cluster of differentiation 98 heavy chain (CD98hc)-specific binding protein, wherein the CD98hc-specific binding protein is a lipocalin 2 (Lcn2)-derived binding protein and binds to CD98hc with a KD of 200 nM or lower.
(FR)
La présente invention concerne une protéine de liaison spécifique du cluster de différenciation 98 à chaîne lourde (CD98hc), la protéine de liaison spécifique de CD98hc étant une protéine de liaison dérivée de lipocaline 2 (Lcn2) et se liant à CD98hc avec un KD inférieur ou égal à 200 nM.
Also published as
Latest bibliographic data on file with the International Bureau