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1. WO2020193267 - SAMPLING DEVICE FOR COLLECTING A MICROBIOTA SAMPLE

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[ EN ]

CLAIMS

1 . A sampling device for collecting a microbiota sample from a gastrointestinal system comprising:

a reservoir for receiving the microbiota sample;

an inlet providing a passage between the reservoir and an outside of the sampling device;

an inlet closure assembly for passively controlling the communication between the reservoir and the outside of the sampling device through the inlet; the inlet closure assembly comprising:

an outer closure for temporary closing the inlet, the outer closure configured to dissolve at a sampling site for allowing the microbiota sample to enter into the reservoir through the inlet; and

an inner closure configured to block the inlet after collecting the microbiota sample.

2. A sampling device according to claim 1 , wherein the inner closure comprises an expandable element configured to expand in an aqueous medium.

3. A sampling device according to claim 2, wherein at least a portion of the expandable element is arranged inside the inlet.

4. A sampling device according to any of claims 2 - 3, wherein at least a portion of the expandable element is arranged inside the reservoir for enclosing the microbiota sample when the expandable element expands.

5. A sampling device according to any of claims 2 - 4, wherein the expandable element is configured to change an expansion rate after a change in pH.

6. A sampling device according to any of claims 2 - 5, wherein the expandable element comprises hydrogel.

7. A sampling device according to any of claims 1 - 6, wherein the outer closure comprises a dissolvable polymer, optionally a polymethacrylate-based copolymer.

8. A sampling device according to any of claims 1 - 7, wherein the sampling device comprises a piston configured to move from a closing position when the outer closure closes the inlet to a receiving position for allowing the microbiota sample to enter into the reservoir.

9. A sampling device according to any of claims 1 - 7, wherein the sampling device is configured in such a way that a pressure in the reservoir is lower than a pressure outside of the sampling device when the outer closure closes the inlet.

10. A sampling device according to any of claims 1 - 9, wherein the sampling device comprises:

an additional reservoir configured to contain an aqueous medium, and an outlet providing a passage between the additional reservoir and the outside of the sampling device.

1 1 . A sampling device for collecting a microbiota sample from a gastrointestinal system comprising:

a first reservoir for receiving the microbiota sample;

a second reservoir comprising an aqueous medium;

a first reservoir inlet providing a passage between the first reservoir and an outside of the sampling device;

a first reservoir inlet closure assembly for controlling the communication between the first reservoir and the outside of the sampling device;

a second reservoir outlet providing a passage between the second reservoir and the outside of the sampling device;

a second reservoir outlet closure assembly for controlling the communication between the second reservoir and the outside of the sampling device;

wherein the second reservoir outlet closure assembly is configured to open when the first reservoir inlet closure assembly opens, such that the aqueous medium is delivered through the second reservoir outlet.

12. A sampling device according to claim 1 1 , wherein the second reservoir outlet closure assembly and/or the first reservoir inlet closure assembly is passive.

13. A sampling device according to claim 12, wherein the second reservoir outlet closure assembly is configured to dissolve at a sampling site to deliver an aqueous medium contained in the second reservoir.

14. A sampling device according to any of claims 1 - 13, wherein the second

reservoir outlet closure assembly is configured to dissolve in a predetermined range of pH and/or in a predetermined range of temperatures and/or after a time of the sampling device inside the gastrointestinal system.

15. A method for collecting a microbiota sample from a gastrointestinal system comprising administering a sampling device according to any of claims 1 - 14 to an animal, optionally a human.