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1. WO2020192803 - CHIMERIC ANTIGEN RECEPTOR RECOMBINANT ADENO-ASSOCIATED VIRUS PARTICLE AND APPLICATION THEREOF

Publication Number WO/2020/192803
Publication Date 01.10.2020
International Application No. PCT/CN2020/091185
International Filing Date 20.05.2020
IPC
C07K 19/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
C12N 15/62 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
C12N 15/867 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
867Retroviral vectors
A61K 35/17 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 南京安锐生物科技有限公司 ABREV BIOTECHNOLOGY CO., LTD. [CN]/[CN]
Inventors
  • 吴喜林 WU, Xilin
  • 吴稚伟 WU, Zhiwei
  • 纳瓦兹瓦卡斯 NAWAZ, Waqas
  • 黄碧莲 HUANG, Bilian
Agents
  • 北京轻创知识产权代理有限公司 KEYCOM PARTNERS, P.C.
Priority Data
201910224056.822.03.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) CHIMERIC ANTIGEN RECEPTOR RECOMBINANT ADENO-ASSOCIATED VIRUS PARTICLE AND APPLICATION THEREOF
(FR) PARTICULE VIRALE ADÉNO-ASSOCIÉE RECOMBINANTE DE RÉCEPTEUR D'ANTIGÈNE CHIMÉRIQUE ET SON APPLICATION
(ZH) 一种嵌合抗原受体重组腺相关病毒颗粒及其应用
Abstract
(EN)
Provided is a chimeric antigen receptor recombinant adeno-associated virus particle, which is a recombinant adeno-associated virus particle carrying a chimeric antigen receptor gene. Also provided is an application of the chimeric antigen receptor recombinant adeno-associated virus particle, and a pharmaceutical composition including the chimeric antigen receptor recombinant adeno-associated virus particle. Recombinant adeno-associated virus particles loaded with chimeric antigen receptors are injected directly into the body, the chimeric antigen receptor recombinant adeno-associated virus particles directly infect T cells or NK cells within the body, and CAR cells are formed directly within the body, so as to implement cell therapy with direct target cell killing.
(FR)
La présente invention concerne une particule virale adéno-associée recombinante de récepteur d'antigène chimérique, qui est une particule virale adéno-associée recombinante portant un gène de récepteur d'antigène chimérique. L'invention concerne également une application de la particule virale adéno-associée recombinante de récepteur d'antigène chimérique, et une composition pharmaceutique comprenant la particule virale adéno-associée recombinante de récepteur d'antigène chimérique. Des particules virales adéno-associées recombinantes chargées de récepteurs d'antigènes chimériques sont injectées directement dans le corps, les particules virales adéno-associées recombinantes de récepteurs d'antigènes chimériques infectent directement les lymphocytes T ou les cellules NK à l'intérieur du corps, et des cellules CAR sont formées directement à l'intérieur du corps, de façon à mettre en œuvre une thérapie cellulaire avec destruction directe de cellules cibles.
(ZH)
提供了一种嵌合抗原受体重组腺相关病毒颗粒,其为携带有嵌合抗原受体基因的重组腺相关病毒颗粒,还提供了该嵌合抗原受体重组腺相关病毒颗粒的应用以及包含有上述嵌合抗原受体重组腺相关病毒颗粒的药物组合物。将装载有嵌合抗原受体的重组腺相关病毒颗粒直接注射体内,在体内该嵌合抗原受体重组腺相关病毒颗粒直接感染T细胞或者NK细胞,在体内直接形成CAR细胞,从而实现直接靶细胞杀伤的细胞治疗。
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