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1. WO2020192606 - APPLICATION OF KDM5A GENE AND ATRX GENE

Publication Number WO/2020/192606
Publication Date 01.10.2020
International Application No. PCT/CN2020/080579
International Filing Date 23.03.2020
IPC
C12Q 1/6886 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
A61K 31/47 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 深圳微芯生物科技股份有限公司 SHENZHEN CHIPSCREEN BIOSCIENCES, CO., LTD. [CN]/[CN]
Inventors
  • 鲁先平 LU, Xianping
  • 山松 SHAN, Song
  • 潘德思 PAN, Desi
  • 宁志强 NING, Zhiqiang
Agents
  • 深圳市深佳知识产权代理事务所(普通合伙) SHENPAT INTELLECTUAL PROPERTY AGENCY
Priority Data
201910228411.925.03.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) APPLICATION OF KDM5A GENE AND ATRX GENE
(FR) APPLICATION D'UN GÈNE KDM5A ET D'UN GÈNE ATRX
(ZH) KDM5A基因和ATRX基因的应用
Abstract
(EN)
The present invention provides application of KDM5A gene and/or ATRX gene as biomarkers in evaluating efficacy of Chiauranib or guiding administration of Chiauranib, and use of Chiauranib in preparation of drugs for treating small cell lung cancer patients with gene mutations in KDM5A gene or ATRX gene.
(FR)
La présente invention concerne l'application du gène KDM5A et/ou du gène ATRX en tant que biomarqueurs dans l'évaluation de l'efficacité de Chiauranib ou le guidage de l'administration de Chiauranib, et l'utilisation de Chiauranib dans la préparation de médicaments pour le traitement de patients atteints d'un cancer du poumon à petites cellules avec des mutations géniques dans le gène KDM5A ou le gène ATRX.
(ZH)
本发明提供KDM5A基因和/或ATRX基因作为生物标志物在评价西奥罗尼疗效或指导西奥罗尼用药中的应用,以及西奥罗尼在制备用于治疗KDM5A基因或ATRX基因存在基因突变的小细胞肺癌患者的药物中的用途。
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