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1. WO2020192581 - WEE1 INHIBITOR AND PREPARATION AND USE THEREOF

Publication Number WO/2020/192581
Publication Date 01.10.2020
International Application No. PCT/CN2020/080401
International Filing Date 20.03.2020
IPC
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/519 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61K 31/5377 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
5377not condensed and containing further heterocyclic rings, e.g. timolol
A61K 31/541 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
541Non-condensed thiazines containing further heterocyclic rings
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 首药控股(北京)有限公司 SHOUYAO HOLDINGS (BEIJING) CO., LTD. [CN]/[CN]
Inventors
  • 朱岩 ZHU, Yan
  • 姚金锁 YAO, Jinsuo
  • 王业柳 WANG, Yeliu
  • 严勤 YAN, Qin
  • 何伟男 HE, Weinan
  • 陈昌俊 CHEN, Changjun
  • 商现星 SHANG, Xianxing
  • 李继军 LI, Jijun
  • 孙颖慧 SUN, Yinghui
  • 李红娟 LI, Hongjuan
  • 路畅 LU, Chang
  • 张久庆 ZHANG, Jiuqing
  • 侯登 HOU, Deng
  • 张晓军 ZHANG, Xiaojun
  • 刘琦超 LIU, Qichao
Agents
  • 北京路浩知识产权代理有限公司 CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED
Priority Data
201910225653.222.03.2019CN
201910972247.214.10.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) WEE1 INHIBITOR AND PREPARATION AND USE THEREOF
(FR) INHIBITEUR DE WEE1 AINSI QUE SA PRÉPARATION ET SON UTILISATION
(ZH) WEE1抑制剂及其制备和用途
Abstract
(EN)
The present invention relates to a WEE1 inhibitor and preparation and use thereof. The WEE1 inhibitor of the present invention is a compound of Formula I or a compound of Formula II, or their pharmaceutically acceptable salts, solvates, polymorphs, or isomers. The present invention also provides the use of the WEE1 inhibitor in the preparation of a medicine for treating diseases related to WEE1 activity. The WEE1 inhibitor provided by the present invention can effectively treat diseases related to WEE1 activity. (I), (II)
(FR)
La présente invention concerne un inhibiteur de WEE1 ainsi que sa préparation et son utilisation. L'inhibiteur de WEE1 de la présente invention est un composé de Formule I ou un composé de Formule II, ou leurs sels, solvates, polymorphes ou isomères pharmaceutiquement acceptables. La présente invention concerne également l'utilisation de l'inhibiteur de WEE1 dans la préparation d'un médicament pour le traitement de maladies liées à l'activité de WEE1. L'inhibiteur de WEE1 selon la présente invention peut traiter efficacement des maladies associées à l'activité de WEE1. (I), (II)
(ZH)
本发明涉及WEE1抑制剂及其制备和用途。本发明所述WEE1抑制剂为式I化合物或式II化合物、或它们的药学上可接受的盐、溶剂化物、多晶型物或异构体。本发明同时提供了所述WEE1抑制剂在制备用来治疗跟WEE1活性相关的疾病的药物中的用途。本发明提供的WEE1抑制剂可有效治疗跟WEE1活性相关的疾病。 (I), (II)
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