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1. WO2020191918 - COMPOSITE MATERIAL OF SYNTHETIC POLYMER AND NATURAL EXTRACELLULAR MATRIX, ARTIFICIAL BLOOD VESSEL, AND PREPARATION METHOD THEREOF

Publication Number WO/2020/191918
Publication Date 01.10.2020
International Application No. PCT/CN2019/089734
International Filing Date 01.06.2019
IPC
A61L 27/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
14Macromolecular materials
18obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L 27/36 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
36containing ingredients of undetermined constitution or reaction products thereof
A61L 27/50 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
A61L 27/56 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
56Porous or cellular materials
A61L 27/58 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
58Materials at least partially resorbable by the body
CPC
A61L 27/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
14Macromolecular materials
18obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L 27/3633
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
3604characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
3633Extracellular matrix [ECM]
A61L 27/507
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
50Materials characterised by their function or physical properties ; , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
507for artificial blood vessels
A61L 27/56
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
50Materials characterised by their function or physical properties ; , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
56Porous materials, ; e.g. foams or sponges
A61L 27/58
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
50Materials characterised by their function or physical properties ; , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
58Materials at least partially resorbable by the body
Applicants
  • 南开大学 NANKAI UNIVERSITY [CN]/[CN]
Inventors
  • 孔德领 KONG, Deling
  • 董显豪 DONG, Xianhao
  • 朱美峰 ZHU, Meifeng
Agents
  • 北京劲创知识产权代理事务所(普通合伙) BEIJING JINCHUANG INTELLECTUAL PROPERTY AGENCY FIRM
Priority Data
201910230829.326.03.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) COMPOSITE MATERIAL OF SYNTHETIC POLYMER AND NATURAL EXTRACELLULAR MATRIX, ARTIFICIAL BLOOD VESSEL, AND PREPARATION METHOD THEREOF
(FR) MATÉRIAU COMPOSITE DE POLYMÈRE SYNTHÉTIQUE ET MATRICE EXTRACELLULAIRE NATURELLE, ET VAISSEAU SANGUIN ARTIFICIEL ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 一种合成高分子与天然细胞外基质复合材料、人工血管及其制备方法
Abstract
(EN)
A composite material of a degradable synthetic polymer and a natural extracellular matrix, an artificial blood vessel prepared therefrom, and a preparation method for the artificial blood vessel. The artificial blood vessel can be prepared using various techniques such as electrospinning, wet spinning, melt spinning, 3D printing, casting, phase separation, particulate leaching, etc. One or a plurality of material ratios can be selected for the degradable synthetic polymer component in the preparation of the artificial blood vessel. The natural extracellular matrix component can be selected from various animal-derived vascular tissues (such as pig and bovine arteries, veins, etc.) or human donor vascular tissues, and its composition and content can be flexibly adjusted according to needs. The composite material and the artificial blood vessel prepared by the preparation technique have good mechanical properties, controllable spatial structures, and suitable degradation rates, and also have excellent biocompatibility and induction of biological activity.
(FR)
L'invention concerne un matériau composite d'un polymère synthétique dégradable et d'une matrice extracellulaire naturelle, un vaisseau sanguin artificiel préparé à partir de ceux-ci, et un procédé de préparation du vaisseau sanguin artificiel. Le vaisseau sanguin artificiel peut être préparé à l'aide de diverses techniques telles que l'électrofilage, le filage par voie humide, le filage par fusion, l'impression 3D, le coulage, la séparation de phase, la lixiviation particulaire, etc. Une ou plusieurs proportions de matière peuvent être sélectionnées pour le composant polymère synthétique dégradable dans la préparation du vaisseau sanguin artificiel. Le composant de matrice extracellulaire naturelle peut être choisi parmi divers tissus vasculaires dérivés d'animaux (tels que des artères de porcs et de bovins, des veines, etc.) ou des tissus vasculaires de donneurs humains, et sa composition et son contenu peuvent être ajustés de manière flexible selon les besoins. Le matériau composite et le vaisseau sanguin artificiel préparés par la technique de préparation présentent de bonnes propriétés mécaniques, des structures spatiales contrôlables et des taux de dégradation appropriés, et possèdent également une excellente biocompatibilité et induction d'activité biologique.
(ZH)
可降解合成高分子与天然细胞外基质复合材料、由其制备的人工血管及人工血管的制备方法。人工血管可通过静电纺丝、湿法纺丝、熔融纺丝、3D打印、浇筑、相分离、粒子沥滤等多种技术制备。人工血管制备过程中的可降解合成高分子组分可选择一种或多种材料配比。天然细胞外基质组分可选择不同种动物来源的血管组织(如猪、牛的动脉、静脉等)或者人类捐献者的血管组织,并且可根据需求灵活调整其成分与含量。通过该制备技术制得的复合材料与人工血管既具有良好的力学性能、可控的空间结构及适宜的降解速度,又具有极佳的生物相容性与生物诱导活性。
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