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1. WO2020186267 - PLATELET-DERIVED GROWTH FACTOR FORMULATIONS FOR ENHANCING BONE FUSION

Publication Number WO/2020/186267
Publication Date 17.09.2020
International Application No. PCT/US2020/022992
International Filing Date 16.03.2020
IPC
A61L 27/54 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
54Biologically active materials, e.g. therapeutic substances
CPC
A61K 38/1858
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
1858Platelet-derived growth factor [PDGF]
A61L 2300/414
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2300Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
40characterised by a specific therapeutic activity or mode of action
412Tissue-regenerating or healing or proliferative agents
414Growth factors
A61L 2430/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2430Materials or treatment for tissue regeneration
02for reconstruction of bones; weight-bearing implants
A61L 2430/38
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2430Materials or treatment for tissue regeneration
38for reconstruction of the spine, vertebrae or intervertebral discs
A61L 27/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
14Macromolecular materials
22Polypeptides or derivatives thereof ; , e.g. degradation products
24Collagen
A61L 27/425
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
42having an inorganic matrix
425of phosphorus containing material, e.g. apatite
Applicants
  • BIOMIMETIC THERAPEUTICS, LLC [US]/[US]
Inventors
  • SUNDARARAJ, Sharath
  • SHOCKLEY, Robert K.
  • YOUNG, Conan S.
  • BROWNING, Carrie
Agents
  • LANG, Hilary
Priority Data
62/818,10414.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PLATELET-DERIVED GROWTH FACTOR FORMULATIONS FOR ENHANCING BONE FUSION
(FR) FORMULATIONS DE FACTEURS DE CROISSANCE DÉRIVÉS DE PLAQUETTES POUR AMÉLIORER LA FUSION OSSEUSE
Abstract
(EN)
The present disclosure provides improved compositions comprising a solution of a platelet-derived growth factor and a biocompatible matrix that are useful for bone fusion procedures, such as spine fusion procedures. The compositions advantageously comprise a the PDGF solution and biocompatible matrix in about a 2:1 volume to weight (mL:g) ratio such that the compositions can be readily applied to a site of bone fusion using a syringe or cannula. In particular embodiments, the composition is useful in conjunction with a spine fusion cage in a spine fusion procedure. The present disclosure also provides methods of performing fusion procedures, such as spine fusion, and kits for fusion procedures.
(FR)
La présente invention concerne des compositions améliorées comprenant une solution d'un facteur de croissance dérivé des plaquettes et une matrice biocompatible qui sont utiles pour des procédures de fusion osseuse, telles que des procédures de fusion de la colonne vertébrale. Les compositions comprennent avantageusement une solution de PDGF et une matrice biocompatible dans un rapport de volume d'environ 2/1 volume à poids (ml/g) de telle sorte que les compositions peuvent être facilement appliquées à un site de fusion osseuse à l'aide d'une seringue ou d'une canule. Dans des modes de réalisation particuliers, la composition est utile conjointement avec une cage de fusion vertébrale dans une procédure de fusion de la colonne vertébrale. La présente invention concerne également des procédés de réalisation de procédés de fusion, telles que la fusion de la colonne vertébrale, et des kits pour des procédures de fusion.
Latest bibliographic data on file with the International Bureau