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1. WO2020186247 - COMPOSITIONS AND METHODS FOR PROMOTING ISLET VIABILITY AND ENHANCING INSULIN SECRETION

Publication Number WO/2020/186247
Publication Date 17.09.2020
International Application No. PCT/US2020/022822
International Filing Date 13.03.2020
IPC
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 38/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
A61K 35/39 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
37Digestive system
39Pancreas; Islets of Langerhans
CPC
A61K 35/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
37Digestive system
39Pancreas; Islets of Langerhans
A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 38/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
Applicants
  • UNIVERSITY OF VIRGINIA PATENT FOUNDATION [US]/[US]
Inventors
  • LAURIE, Gordon, W.
  • BRAYMAN, Kenneth
  • CHHABRA, Preeti
  • MA, Mingyang
  • TEIXEIRA, Karina
  • GADEK, Thomas, R.
Agents
  • PERKINS, Christopher, P.
Priority Data
62/817,79013.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR PROMOTING ISLET VIABILITY AND ENHANCING INSULIN SECRETION
(FR) COMPOSITIONS ET MÉTHODES POUR FAVORISER LA VIABILITÉ DES ÎLOTS ET AMÉLIORER LA SÉCRÉTION D'INSULINE
Abstract
(EN)
Compositions and methods for regenerating pancreatic islet viability and/or cell proliferation in vitro, ex vivo, and/or in vivo; and/or for regenerating glucose-stimulated insulin secretion; and/or for regenerating viability and/or cell proliferation of a transplanted pancreatic islets; and/or for preventing and/or inhibiting rejection of a transplanted islets; and/or for pancreatic islet transplantation; and/or for treating a symptom of a condition, disorder, or disease associated with abnormal insulin responsiveness to glucose are provided. In some embodiments, the compositions include a peptide and/or a pharmaceutically acceptable salt thereof, and/or a biologically active fragment, analog, or derivative thereof, wherein the peptide, the pharmaceutically acceptable salt thereof, and/or the biologically active fragment, analog, or derivative thereof has an amino acid sequence of any of SEQ ID NOs: 1-60, or any combination thereof.
(FR)
L'invention concerne des compositions et des méthodes pour régénérer la viabilité des îlots pancréatiques et/ou la prolifération cellulaire in vitro, ex vivo et/ou in vivo; et/ou régénérer la sécrétion d'insuline stimulée par le glucose; et/ou régénérer la viabilité et/ou la prolifération cellulaire d'îlots pancréatiques transplantés; et/ou pour prévenir et/ou inhiber le rejet d'îlots transplantés; et/ou pour transplanter des îlots pancréatiques; et/ou pour traiter un symptôme d'une affection, d'un trouble ou d'une maladie associée à une réponse anormale de l'insuline au glucose. Dans certains modes de réalisation, les compositions comprennent un peptide et/ou un sel pharmaceutiquement acceptable de celui-ci, et/ou un fragment biologiquement actif, un analogue ou un dérivé de celui-ci, le peptide, le sel pharmaceutiquement acceptable de celui-ci, et/ou le fragment biologiquement actif, l'analogue ou un dérivé de celui-ci ayant une séquence d'acides aminés selon l'une quelconque des SEQ ID NO : 1 à 60, ou toute combinaison de ceux-ci.
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