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1. WO2020182858 - A METHOD FOR DETECTION OF AN ENANTIOMERIC EXCESS OF CHIRAL MOLECULES IN LIQUID PHASE AND A SENSITIVE DETECTOR OF THE CHIRALITY OF A MEDIUM

Publication Number WO/2020/182858
Publication Date 17.09.2020
International Application No. PCT/EP2020/056458
International Filing Date 11.03.2020
IPC
G01N 21/21 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
21Polarisation-affecting properties
G01N 21/64 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
CPC
G01N 2021/216
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
21Polarisation-affecting properties
216using circular polarised light
G01N 2021/391
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
39using tunable lasers
391Intracavity sample
G01N 21/21
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
21Polarisation-affecting properties
G01N 21/6445
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
6445Measuring fluorescence polarisation
Applicants
  • ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG [DE]/[DE]
Inventors
  • BUHMANN, Stefan Yoshi
  • BENNETT, Robert
  • GORBACHEV, Yaroslav
Agents
  • RÖSLER, Uwe
Priority Data
62/818,50514.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A METHOD FOR DETECTION OF AN ENANTIOMERIC EXCESS OF CHIRAL MOLECULES IN LIQUID PHASE AND A SENSITIVE DETECTOR OF THE CHIRALITY OF A MEDIUM
(FR) PROCÉDÉ DE DÉTECTION D'UN EXCÈS ÉNANTIOMÈRE DE MOLÉCULES CHIRALES EN PHASE LIQUIDE ET DÉTECTEUR SENSIBLE DE LA CHIRALITÉ D'UN MILIEU
Abstract
(EN)
A new, extremely sensitive detector for the chirality of molecules in the liquid phase based on photonic Bose-Einstein condensation is proposed, where the chiral molecules are being sent through a cavity formed by two curved mirrors. Dye molecules driven by an external unpolarised laser serve as the detector: The condensed dye-assisted laser light emerging from the cavity is extremely sensitive to any chiral molecules present; it is almost purely right-circularly polarised for a tiny excess of left-handed molecules (enantiomers) and vice versa. The sensitivity of the detector stems from a winner-takes-it-all effect where the energy of the external laser is almost exclusively directed towards the standing wave inside the cavity that has the lowest energy. This will be either a left-or right-handed polarised wave in the presence of an enantiomeric excess of left-or right-handed molecules.
(FR)
L'invention concerne un nouveau détecteur extrêmement sensible pour la chiralité de molécules dans la phase liquide basé sur la condensation de Bose-Einstein photonique, où les molécules chirales sont envoyées à travers une cavité formée par deux miroirs incurvés. Des molécules de colorant entraînées par un laser non polarisé externe servent de détecteur. La lumière laser assistée par colorant condensé émergeant de la cavité est extrêmement sensible à toutes les molécules chirales présentes ; elle est presque purement à polarisation circulaire à droite pour un minuscule excès de molécules lévogyres (énantiomères) et vice versa. La sensibilité du détecteur découle d'un effet vainqueur-emporte-tout où l'énergie du laser externe est presque exclusivement dirigée vers l'onde stationnaire à l'intérieur de la cavité qui possède l'énergie la plus faible. Ceci sera une onde à polarisation soit gauche soit droite en présence d'un excès énantiomère de molécules à lévogyres ou dextrogyres.
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