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1. WO2020182109 - CRYSTAL FORM OF DEUTERIUM ATOM-SUBSTITUTED INDOLE FORMAMIDE DERIVATIVE AND PREPARATION METHOD THEREFOR

Publication Number WO/2020/182109
Publication Date 17.09.2020
International Application No. PCT/CN2020/078506
International Filing Date 10.03.2020
IPC
C07D 209/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
04Indoles; Hydrogenated indoles
10with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
12Radicals substituted by oxygen atoms
C07D 401/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
A61K 31/404 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
404Indoles, e.g. pindolol
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/404
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
404Indoles, e.g. pindolol
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 209/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
04Indoles; Hydrogenated indoles
10with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
12Radicals substituted by oxygen atoms
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • 江苏恒瑞医药股份有限公司 JIANGSU HENGRUI MEDICINE CO., LTD. [CN]/[CN]
  • 上海恒瑞医药有限公司 SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. [CN]/[CN]
Inventors
  • 陈杰 CHEN, Jie
  • 尤凌峰 YOU, Lingfeng
  • 冯君 FENG, Jun
  • 贺峰 HE, Feng
  • 刘明明 LIU, Mingming
  • 杜振兴 DU, Zhenxing
Agents
  • 上海弼兴律师事务所 SHANGHAI BESHINING LAW OFFICE
Priority Data
201910179875.511.03.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) CRYSTAL FORM OF DEUTERIUM ATOM-SUBSTITUTED INDOLE FORMAMIDE DERIVATIVE AND PREPARATION METHOD THEREFOR
(FR) FORME CRISTALLINE D'UN DÉRIVÉ D'INDOLE-FORMAMIDE SUBSTITUÉ PAR UN ATOME DE DEUTÉRIUM ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 氘原子取代的吲哚甲酰胺类衍生物的晶型及其制备方法
Abstract
(EN)
A crystal form of a deuterium atom-substituted indole formamide derivative with structure shown in formula I and a preparation method therefor. The crystal form of the compound represented by formula (I) exhibits good stability and may be better used in clinical treatment.
(FR)
L'invention concerne une forme cristalline d'un dérivé d'indole-formamide substitué par un atome de deutérium avec une structure représentée par la formule I et son procédé de préparation. La forme cristalline du composé représenté par la formule (I) présente une stabilité satisfaisante et peut être mieux utilisée dans un traitement clinique.
(ZH)
一种具有式I所示结构的氘原子取代的吲哚甲酰胺类衍生物的晶型及其制备方法。式(I)所示化合物的晶型具备良好的稳定性,可更好地用于临床治疗。
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