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1. WO2020180849 - PURE CONDUCTING POLYMER HYDROGEL AND HYDROGEL PRECURSOR MATERIALS HAVING EXTRAORDINARY ELECTRICAL AND SWELLING PROPERTIES AND METHODS OF MAKING

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[ EN ]

What is claimed is:

1. A pure conducting polymer hydrogel comprising:

at least about 50 wt% water, based on total weight of the pure conducting polymer hydrogel; and

up to about 50 wt% of a conducting polymer component, the conducting polymer component comprising at least about 99% of one or more conducting polymers and less than about 1% of additives, crosslinkers and materials other than the one or more conducting polymers, wherein the pure conducting polymer hydrogel has an electrical conductivity of at least about 1 S cm in PBS and at least about 1 S cm 1 in deionized water, a stretchability of at least about 10 % strain, and a Young’s modulus of no greater than about 20 MPa.

2. The hydrogel of claim 1, wherein the one or more conducting polymers are selected from one or more polythiophenes.

3. The hydrogel of claim 2, wherein the one or more conducting polymers are selected from poly(3,4- ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS), poly(3,4-ethylenedioxyselenophene) (PEDOS), poly(3,4-ethylenedithiathiophene)

(PEDTT), poly(thieno[3,4-b]-l,4-oxathiane) (PEOTT), poly(N-m ethyl-3, 4-dihydrothieno[3, 4-b][l,4]oxazine) (PMDTO), poly(hydroxymethylated-3,4-ethylenedioxylthiophene) (PEDOT-MeOH), and combinations thereof.

4. The hydrogel of claim 2, wherein the one or more conducting polymers is poly(3,4-

ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS).

5. The hydrogel of claim 1, having an electrical conductivity of at least about 10 S cm 1 in PBS and at least about 20 S cm 1 in deionized water.

6. The hydrogel of claim 5, having an electrical conductivity of at least about 20 S cm 1 in PBS and at least about 40 S cm 1 in deionized water.

7. The hydrogel of claim 1, having a stretchability of at least about 20% strain.

8. The hydrogel of claim 1, having a stretchability of at least about 35% strain.

9. The hydrogel of claim 1, having a Young’s modulus of no greater than about 10 MPa.

10. The hydrogel of claim 1, having a Young’s modulus of no greater than about 2 MPa

11. The hydrogel of claim 1, comprising at least about 80 wt% water, based on total weight of the pure conducting polymer hydrogel, and up to about 20 wt% of the conducting polymer component.

12. A pure conducting polymer hydrogel precursor comprising:

at least about 99% of one or more conducting polymers; and

less than about 1% of additives, crosslinkers and materials other than the one or more conducting polymers;

wherein placing the hydrogel precursor in a wet environment hydrates and swells the hydrogel precursor to form a hydrogel, the hydrogel having an electrical conductivity of at least about 1 S cm in PBS and at least about 1 S cm 1 in deionized water, a stretchability of at least about 10 % strain, and a Young’s modulus of no greater than about 20 MPa.

13. The hydrogel precursor of claim 12, having one or more predetermined swelling properties.

14. The hydrogel precursor of claim 13, wherein the predetermined swelling property is anisotropic swelling.

15. The hydrogel precursor of claim 14, wherein the hydrogel precursor is in the form of a film that swells in a thickness direction.

16. The hydrogel precursor of claim 13, wherein the predetermined swelling property is isotropic swelling.

17. The hydrogel precursor of claim 12, wherein the one or more conducting polymers are selected from one or more polythiophenes.

18. The hydrogel of claim 17, wherein the one or more conducting polymers are selected from poly(3,4- ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS), poly(3,4-

ethylenedioxyselenophene) (PEDOS), poly(3,4-ethylenedithiathiophene)

(PEDTT), poly(thieno[3,4-b]-l,4-oxathiane) (PEOTT), poly(N-m ethyl-3, 4-dihydrothieno[3, 4-b][l,4]oxazine) (PMDTO), poly(hydroxymethylated-3,4-ethylenedioxylthiophene) (PEDOT-MeOH), and combinations thereof.

19. The hydrogel of claim 17, wherein the one or more conducting polymers is poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS).

20. A method of fabricating a pure conducting polymer hydrogel precursor comprising:

mixing one or more conducting polymers with a first solvent to form an aqueous solution; adding one or more polar organic solvent to the aqueous solution; and

performing dry-annealing to form the hydrogel precursor, the pure conducting polymer hydrogel precursor comprising at least about 99% of one or more conducting polymers and less than about 1% of additives, crosslinkers and materials other than the one or more conducting polymers.

21. The method of claim 20, wherein the one or more conducting polymers are selected from one or more polythiophenes.

22. The method of claim 21, wherein the one or more conducting polymers are selected from poly(3,4- ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS), poly(3,4-ethylenedioxyselenophene) (PEDOS), poly(3,4-ethylenedithiathiophene)

(PEDTT), poly(thieno[3,4-b]-l,4-oxathiane) (PEOTT), poly(N-m ethyl-3, 4-dihydrothieno[3, 4- b][l,4]oxazine) (PMDTO), poly(hydroxymethylated-3,4-ethylenedioxylthiophene) (PEDOT-MeOH), and combinations thereof.

23. The method of claim 21, wherein the one or more conducting polymers is poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS).

24. The method of claim 20, wherein the one or more polar organic solvent is selected from dimethyl sulfoxide (DMSO), ethylene glycol (EG), xylene, methanol, dimethylformamide (DMF), tetrahydrofuran (THF), and combinations thereof.

25. The method of claim 20, wherein dry-annealing is performed to provide one or more tunable swelling properties of the hydrogel precursor in wet physiological environments.

26. The method of claim 25, wherein the dry-annealing is performed under mechanically constrained conditions to form a hydrogel precursor, wherein the hydrogel precursor isotropically swells to form a hydrogel in a wet environment.

27. The method of claim 25, wherein the dry-annealing is performed under mechanically unconstrained conditions to form a hydrogel precursor, wherein the hydrogel precursor anisotropically swells to form a hydrogel in a wet environment.

28. A method of fabricating a pure conducting polymer hydrogel comprising:

mixing one or more conducting polymers with a first solvent to form an aqueous solution; adding one or more polar organic solvent to the aqueous solution; and

performing dry-annealing to form a hydrogel precursor, the hydrogel precursor comprising at least about 99% of one or more conducting polymers and less than about 1% of additives, crosslinkers and materials other than the one or more conducting polymers; and

rehydrating the hydrogel precursor to form the pure conducting polymer hydrogel, wherein the hydrogel has an electrical conductivity of at least about 1 S cm in PBS and at least about 1 S cm 1 in deionized water, a stretchability of at least about 10 % strain, and a Young’s modulus of no greater than about 20 MPa.

29. The method of claim 28, wherein the one or more conducting polymers are selected from one or more polythiophenes.

30. The method of claim 29, wherein the one or more conducting polymers are selected from poly(3,4- ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS), poly(3,4-ethylenedioxyselenophene) (PEDOS), poly(3,4-ethylenedithiathiophene)

(PEDTT), poly(thieno[3,4-b]-l,4-oxathiane) (PEOTT), poly(N-m ethyl-3, 4-dihydrothieno[3, 4-b][l,4]oxazine) (PMDTO), poly(hydroxymethylated-3,4-ethylenedioxylthiophene) (PEDOT-MeOH), and combinations thereof.

31. The method of claim 29, wherein the one or more conducting polymers is poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS).

32. The method of claim 28, wherein the one or more polar organic solvent is selected from dimethyl sulfoxide (DMSO), ethylene glycol (EG), xylene, methanol, dimethylformamide (DMF), tetrahydrofuran (THF), and combinations thereof.

33. The method of claim 28, wherein dry-annealing is performed to provide one or more tunable swelling properties of the hydrogel precursor in wet physiological environments.

34. The method of claim 33, wherein the dry-annealing is performed under mechanically constrained conditions to form a hydrogel precursor, wherein the hydrogel precursor isotropically swells to form a hydrogel in a wet environment.

35. The method of claim 33, wherein the dry-annealing is performed under mechanically unconstrained conditions to form a hydrogel precursor, wherein the hydrogel precursor anisotropically swells to form a hydrogel in a wet environment.