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1. WO2020161257 - 3-AMINO-2-[2-(ACYLAMINO)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE AS CSNK1 INHIBITORS

Publication Number WO/2020/161257
Publication Date 13.08.2020
International Application No. PCT/EP2020/053020
International Filing Date 06.02.2020
IPC
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 471/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
A61K 31/437 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 471/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
Applicants
  • BAYER AKTIENGESELLSCHAFT [DE]/[DE]
  • DANA-FARBER CANCER INSTITUTE, INC. [US]/[US]
  • THE BROAD INSTITUTE, INC. [US]/[US]
Inventors
  • SCHULZE, Volker
  • MENGEL, Anne
  • JENS, Schröder
  • FARIA ALVARES DE LEMOS, Adelaide, Clara
  • BONE, Wilhelm
  • BÖMER, Ulf
  • SÜLZLE, Detlev
  • CHRIST, Clara
  • HILLIG, Roman
  • LECHNER, Christian
  • CORSELLO, Steven
  • HANDING, Kasia
  • CALIMAN, Alisha
  • RAUH, Ulrike
  • KAULFUSS, Stefan
  • MORTIER, Jérémie
Agents
  • BIP PATENTS
Priority Data
62/802,49207.02.2019US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) 3-AMINO-2-[2-(ACYLAMINO)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE AS CSNK1 INHIBITORS
(FR) 3-AMINO-2-[2-(ACYLAMINO)PYRIDIN-4-YL]-1,5-TÉTRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE EN TANT QU'INHIBITEURS DE CSNK1
Abstract
(EN) Compounds of formula (I), processes for their production and their use as pharmaceuticals. The compounds are inhibitors of Casein kinase 1 alpha and/or delta ( CSNK1α and/or 6) useful for the treatment of proliferative disorders. (l)
(FR) L'invention concerne des composés de formule (I), des procédés pour leur production et leur utilisation en tant que produits pharmaceutiques. Les composés sont des inhibiteurs de la caséine kinase 1 alpha et/ou delta (CSNK1α et/ou 6) utiles pour le traitement de troubles prolifératifs. (I)
Related patent documents
US17428730This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
Latest bibliographic data on file with the International Bureau