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1. WO2020158047 - METHOD FOR PRODUCING ESTER COMPOUND

Publication Number WO/2020/158047
Publication Date 06.08.2020
International Application No. PCT/JP2019/038081
International Filing Date 27.09.2019
IPC
C07C 67/03 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
67Preparation of carboxylic acid esters
03by reacting an ester group with a hydroxy group
C07C 69/747 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
74Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
743of acids with a three-membered ring and with unsaturation outside the ring
747Chrysanthemumic acid esters
C07B 61/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
61Other general methods
CPC
C07B 61/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
61Other general methods
C07C 67/03
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
67Preparation of carboxylic acid esters
03by reacting an ester group with a hydroxy group
C07C 69/743
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
74Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
743of acids with a three-membered ring and with unsaturation outside the ring
C07C 69/747
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
74Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
743of acids with a three-membered ring and with unsaturation outside the ring
747Chrysanthemumic acid esters
Applicants
  • 住友化学株式会社 SUMITOMO CHEMICAL COMPANY, LIMITED [JP]/[JP]
Inventors
  • 新井 健二 ARAI, Kenji
Agents
  • 中山 亨 NAKAYAMA, Tohru
  • 坂元 徹 SAKAMOTO, Toru
Priority Data
2019-01677101.02.2019JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD FOR PRODUCING ESTER COMPOUND
(FR) PROCÉDÉ DE PRODUCTION D'UN COMPOSÉ ESTER
(JA) エステル化合物の製造方法
Abstract
(EN) In the present invention, when 2,2-dimethyl-3-((Z)-1-propenyl)cyclopropane carboxylic acid methyl and [4-(methoxymethyl)-2,3,5,6-tetrafluorophenyl]methanol are reacted in an organic solvent in the presence of lithium methoxide to produce [4-(methoxymethyl)-2,3,5,6-tetafluorophenyl]methyl 2,2-dimethyl-3-((Z)-1-propenyl)cyclopropane carboxylate, a mixture of an organic solvent, 2,2-dimethyl-3-((Z)-1-propenyl)cyclopropane carboxylic acid methyl, and [4-(methoxymethyl)-2,3,5,6-tetrafluorophenyl]methanol is washed with a bisulfite aqueous solution and subsequently lithium methoxide is added for reaction. By this method, a target substance can be produced with the generation of impurities being suppressed.
(FR) La présente invention concerne la mise en réaction du méthyle d'acide 2,2-diméthyl-3-((Z)-1-propényl)cyclopropane carboxylique et du [4-(méthoxyméthyl)-2,3,5,6-tétrafluorophényl]méthanol dans un solvant organique en présence de méthoxyde de lithium afin de produire du [4-(méthoxyméthyl)-2,3,5,6-tétafluorophényl]méthyl 2,2-diméthyl-3-((Z)-1-propényl)cyclopropane carboxylate, un mélange d'un solvant organique, du méthyle d'acide 2,2-diméthyl-3-((Z)-1-propényl)cyclopropane carboxylique, et du [4-(méthoxyméthyl)-2,3,5,6-tétrafluorophényl]méthanol étant lavé avec une solution aqueuse bisulfite, puis du méthoxyde de lithium étant ajouté pour la réaction. Ce procédé permet de produire une substance cible avec élimination de la génération d'impuretés.
(JA) 有機溶媒中で2,2-ジメチル-3-((Z)-1-プロペニル)シクロプロパンカルボン酸メチルと[4-(メトキシメチル)-2,3,5,6-テトラフルオロフェニル]メタノールとをリチウムメトキシドの存在下に反応させて[4-(メトキシメチル)-2,3,5,6-テトラフルオロフェニル]メチル 2,2-ジメチル-3-((Z)-1-プロペニル)シクロプロパンカルボキシラートを製造する上で、有機溶媒、2,2-ジメチル-3-((Z)-1-プロペニル)シクロプロパンカルボン酸メチル及び[4-(メトキシメチル)-2,3,5,6-テトラフルオロフェニル]メタノールの混合物を亜硫酸水素塩水溶液で洗浄した後、リチウムメトキシドを加えて反応を行うことにより、不純物の生成を抑制して目的物を製造することができる。
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