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1. WO2020142782 - VITAMIN E AND CANCER THERAPEUTIC COMPOSITIONS AND METHODS

Publication Number WO/2020/142782
Publication Date 09.07.2020
International Application No. PCT/US2020/012423
International Filing Date 06.01.2020
IPC
A61K 38/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
A61K 38/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides ; , e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
Applicants
  • UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE [US]/[US]
  • PAREDOX THERAPEUTICS, LLC [US]/[US]
  • WAKE FOREST UNIVERSITY HEALTH SCIENCES [US]/[US]
Inventors
  • CUNNIFF, Brian
  • FRYKMAN, Gregory
  • NELSON, Kimberly Johnson
Agents
  • ANDERSON, MaryDilys S.
Priority Data
62/788,33204.01.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) VITAMIN E AND CANCER THERAPEUTIC COMPOSITIONS AND METHODS
(FR) COMPOSITIONS ET PROCÉDÉS THÉRAPEUTIQUES CONTRE LE CANCER ET DE VITAMINE E
Abstract
(EN)
The invention relates, in part, to compounds, compositions, and methods useful to treat cancer in cells and subjects. The invention relates, in part, to compounds, compositions, and methods useful to treat cancer in cells and subjects. According to one aspect of the invention, methods for reducing cell viability in a population cells comprising cancer cells are provided, the methods including: contacting a population of cells that include cancer cells with Thiostrepton (TS) and Vitamin E-TPGS, under conditions and for a period of time sufficient for a statistically significant reduction in viability in a plurality of the cancer cells.
(FR)
L'invention concerne, en partie, des composés, des compositions et des méthodes utiles pour traiter le cancer dans des cellules et chez des sujets. L'invention concerne, en partie, des composés, des compositions et des méthodes utiles pour traiter le cancer dans des cellules et chez des sujets. Selon un aspect de l'invention, des procédés de réduction de la viabilité cellulaire dans une population de cellules comprenant des cellules cancéreuses sont décrits, les procédés comprenant les étapes consistant à : mettre en contact une population de cellules qui comprennent des cellules cancéreuses avec du thiosulfate (TS) et de la vitamine E-TPGS, dans des conditions et pendant une période de temps suffisante pour une réduction statistiquement significative de la viabilité dans une pluralité de cellules cancéreuses.
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