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1. WO2020142778 - ATTENUATED BORDETELLA BRONCHISEPTICA STRAINS, ORAL VACCINES CONTAINING THE ATTENUATED STRAINS, AND METHODS OF MAKING & USE THEREOF

Publication Number WO/2020/142778
Publication Date 09.07.2020
International Application No. PCT/US2020/012406
International Filing Date 06.01.2020
IPC
A61K 39/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
CPC
A61K 2039/522
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
52Bacterial cells; Fungal cells; Protozoal cells
522avirulent or attenuated
A61K 2039/5254
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5254avirulent or attenuated
A61K 2039/552
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
55characterised by the host/recipient, e.g. newborn with maternal antibodies
552Veterinary vaccine
A61K 2039/70
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
70Multivalent vaccine
A61K 39/099
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
099Bordetella
C12N 2760/16134
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2760ssRNA Viruses negative-sense
00011ssRNA Viruses negative-sense
16011Orthomyxoviridae
16111Influenzavirus A, i.e. influenza A virus
16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Applicants
  • BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC. [US]/[US]
Inventors
  • FISCHER, Laurent, Bernard
  • JOLIVET, Edmond
  • MILLSAP, Kevin
Agents
  • JARECKI-BLACK, Judy
Priority Data
62/788,76404.01.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ATTENUATED BORDETELLA BRONCHISEPTICA STRAINS, ORAL VACCINES CONTAINING THE ATTENUATED STRAINS, AND METHODS OF MAKING & USE THEREOF
(FR) SOUCHES ATTÉNUÉES DE BORDETELLA BRONCHISEPTICA, VACCINS ORAUX CONTENANT LES SOUCHES ATTÉNUÉES, ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
Abstract
(EN)
The present invention provides attenuated, aroA mutant B. bronchiseptica strains that are effective to elicit an immune response in an animal against B. bronchiseptica. Also provided are immunogenic compositions and vaccines which include the attenuated, aroA mutant B. bronchiseptica strains. Also provided are kits for use with such compositions and vaccines. Also provided are methods of orally administering attenuated, aroA mutant B. bronchiseptica strains, compositions, and vaccines to animals.
(FR)
La présente invention fournit des souches atténuées de B. bronchiseptica aroA mutante qui sont efficaces pour provoquer une réponse immunitaire chez un animal contre la B. bronchiseptica. L'invention concerne également des compositions immunogènes et des vaccins qui comprennent les souches atténuées de B. Bronchiseptica aroA mutante. L'invention concerne aussi des kits destinés à être utilisés avec de telles compositions et de tels vaccins. L'invention concerne en outre des procédés d'administration par voie orale de souches atténuées de B. bronchiseptica aroA mutante, de compositions et de vaccins à des animaux.
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