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1. WO2020142716 - CYCLODEXTRIN DIMERS, COMPOSITIONS THEREOF, AND USES THEREOF

Publication Number WO/2020/142716
Publication Date 09.07.2020
International Application No. PCT/US2020/012225
International Filing Date 03.01.2020
IPC
C08B 37/16 2006.1
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
BPOLYSACCHARIDES; DERIVATIVES THEREOF
37Preparation of polysaccharides not provided for in groups C08B1/-C08B35/110; Derivatives thereof
16Cyclodextrin; Derivatives thereof
A61K 31/724 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
716Glucans
724Cyclodextrins
C08L 5/16 2006.1
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
5Compositions of polysaccharides or of their derivatives not provided for in group C08L1/ or C08L3/142
16Cyclodextrin; Derivatives thereof
CPC
A61K 31/724
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
716Glucans
724Cyclodextrins
C08B 37/0012
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
BPOLYSACCHARIDES; DERIVATIVES THEREOF
37Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
0009alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
0012Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
Applicants
  • UNDERDOG PHARMACEUTICALS, INC. [US]/[US]
Inventors
  • O'CONNOR, Matthew, S.
  • MALANGA, Milo
  • KOPE, Michael
  • TOM, Christina, A.T.M.B.
  • ANDERSON, Amelia, M.
Agents
  • KALAFUS, Kenneth, J.
  • TESKIN, Robin, L.
Priority Data
62/787,86903.01.2019US
62/850,33420.05.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CYCLODEXTRIN DIMERS, COMPOSITIONS THEREOF, AND USES THEREOF
(FR) DIMÈRES DE CYCLODEXTRINE, LEURS COMPOSITIONS ET LEURS UTILISATIONS
Abstract
(EN)
A new class of synthetic cyclodextrin dimers is described. Exemplary cyclodextrin dimers can treat atherosclerotic plaques by targeting various forms cholesterol both intracellularly and extracellularly. Also provided are methods of depleting atherosclerotic plaques of cholesterol, cholesterol esters, 7-ketocholesterol and 7-ketocholesterol esters by treatment with such cyclodextrins. Further described are subclasses of dimers that have high specificity for 7-ketocholesterol.
(FR)
L'invention concerne une nouvelle classe de dimères de cyclodextrine synthétiques. Des dimères de cyclodextrine donnés à titre d'exemple peuvent traiter des plaques athérosclérotiques en ciblant diverses formes de cholestérol à la fois de manière intracellulaire et extracellulaire. L'invention concerne également des procédés de déplétion de plaques athérosclérotiques de cholestérol, d'esters de cholestérol, de 7-cétocholestérol et d'esters de 7-cétocholestérol par traitement avec de telles cyclodextrines. L'invention concerne en outre des sous-classes de dimères qui ont une spécificité élevée pour le 7-cétocholestérol.
Also published as
IL284435
Latest bibliographic data on file with the International Bureau