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1. WO2020142696 - QUANTITATIVE MEASUREMENT OF DISRUPTIONS IN THE BLOOD BRAIN BARRIER

Publication Number WO/2020/142696
Publication Date 09.07.2020
International Application No. PCT/US2020/012191
International Filing Date 03.01.2020
IPC
A61B 5/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
A61B 5/055 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
05Measuring for diagnosis by means of electric currents or magnetic fields
055involving electronic or nuclear magnetic resonance, e.g. magnetic resonance imaging
CPC
A61B 5/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
A61B 5/055
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
055involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
Applicants
  • NORTHEASTERN UNIVERSITY [US]/[US]
Inventors
  • FERRIS, Craig
  • QIAO, Ju
  • KULKARNI, Praveen
  • GHARAGOUZLOO, Codi
Agents
  • GORDON, Dana M.
  • ABELLEIRA, Susan, M.
  • AKHIEZER, Alexander
  • BLOUNT, Jennifer, V.
  • CAI, Mi
Priority Data
62/787,81903.01.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) QUANTITATIVE MEASUREMENT OF DISRUPTIONS IN THE BLOOD BRAIN BARRIER
(FR) MESURE QUANTITATIVE DE PERTURBATIONS DANS LA BARRIÈRE HÉMATO-ENCÉPHALIQUE
Abstract
(EN)
Disclosed are methods for determining blood brain barrier disruption in a subject in need thereof. The methods include administering intravascularly a contrast agent to the subject; performing quantitative ultra-short time-to-echo contrast-enhanced magnetic resonance imaging (QUTE-CE MRI) on a region of interest of the subject's brain; and determining presence of the contrast agent in brain parenchyma and/or cerebral spinal fluid within the region of interest.
(FR)
La présente invention concerne des procédés de détermination de perturbation dans la barrière hémato-encéphalique chez un sujet en ayant besoin. Les procédés comprennent l’administration de manière intravasculaire d’un agent de contraste au sujet ; l’exécution d’une imagerie par résonance magnétique à contraste amélioré quantitative à temps d’écho ultra-court (QUTE-CE MRI) sur une région d’intérêt du cerveau d’un sujet ; et la détermination de la présence de l’agent de contraste dans le parenchyme cérébral et/ou le liquide spinal cérébral à l’intérieur de la région d’intérêt.
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