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1. WO2020142206 - NASAL DRUG DELIVERY DEVICE

Publication Number WO/2020/142206
Publication Date 09.07.2020
International Application No. PCT/US2019/066921
International Filing Date 17.12.2019
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61M 11/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
11Sprayers or atomisers specially adapted for therapeutic purposes
A61M 11/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
11Sprayers or atomisers specially adapted for therapeutic purposes
02operated by air pressure applied to the liquid to be sprayed or atomised
A61M 15/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
15Inhalators
A61M 15/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
15Inhalators
08Inhaling devices inserted into the nose
CPC
A61M 11/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
11Sprayers or atomisers specially adapted for therapeutic purposes
02operated by air ; or other gas; pressure applied to the liquid ; or other product; to be sprayed or atomised
A61M 15/0021
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
15Inhalators
0001Details of inhalators; Constructional features thereof
0021Mouthpieces therefor
A61M 15/0043
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
15Inhalators
0028using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
003using capsules, e.g. to be perforated or broken-up
0043Non-destructive separation of the package, e.g. peeling
A61M 15/0071
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
15Inhalators
0065Inhalators with dosage or measuring devices
0068Indicating or counting the number of dispensed doses or of remaining doses
007Mechanical counters
0071having a display or indicator
A61M 15/009
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
15Inhalators
009using medicine packages with incorporated spraying means, e.g. aerosol cans
A61M 15/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
15Inhalators
08Inhaling devices inserted into the nose
Applicants
  • IMPEL NEUROPHARMA, INC. [US]/[US]
Inventors
  • FULLER, Christopher William
  • KOHRING, Craig Frederick
  • LAVIN, Albert Kenneth
  • HOEKMAN, John D.
Agents
  • AMSEL, Jason E.
  • BAILEY, F., Pinar
  • FOULDS, Glenn, J.
  • SEQUEIRA, Antonia, L.
  • BECKER, Daniel, M.
Priority Data
62/788,09303.01.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NASAL DRUG DELIVERY DEVICE
(FR) DISPOSITIF D'ADMINISTRATION DE MÉDICAMENT PAR VOIE NASALE
Abstract
(EN)
A nasal drug delivery device for delivering a plume derived from a propellant and a drug compound. The drug compound is in an intranasal dosage form in the form of powder, suspension, dispersion, or liquid. The propelled intranasal dosage form is deposited within the upper nasal cavity such as the olfactory region. The drug deposited within the olfactory region is delivered to the brain avoiding the blood-brain-barrier. Hydrofluoroalkane propellant from a pressurized canister is channeled to a diffuser and drug-containing channel where the intranasal dosage form is aerosolized. The aerosolized intranasal dosage form passes through a nozzle thus delivering a plume to the user's upper nasal cavity.
(FR)
La présente invention se rapporte à un dispositif d'administration de médicament par voie nasale destiné à administrer un jet dérivé d'un agent propulseur et un composé de médicament. Le composé de médicament est produit sous une forme posologique intranasale ayant la forme d'une poudre, d'une suspension, d'une dispersion ou d'un liquide. La forme posologique intranasale propulsée est déposée dans la cavité nasale supérieure telle que la région olfactive. Le médicament déposé dans la région olfactive est administré au cerveau, évitant ainsi la barrière hémato-encéphalique. L'agent propulseur hydrofluoroalcane provenant d'un récipient sous pression est orienté vers un diffuseur et une chambre qui contient le médicament où la forme posologique intranasale se trouve sous une forme aérosolisée. La forme posologique intranasale sous une forme aérosolisée passe à travers une buse, ce qui permet d'administrer un jet à la cavité nasale supérieure de l'utilisateur.
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