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1. WO2020142102 - CONOTOXIN PEPTIDE ANALOGS AND USES FOR THE TREATMENT OF PAIN AND INFLAMMATORY CONDITIONS

Publication Number WO/2020/142102
Publication Date 09.07.2020
International Application No. PCT/US2019/012307
International Filing Date 04.01.2019
IPC
C07K 14/435 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 47/60
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
59obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
60the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
C07K 14/43504
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
43504from invertebrates
C07K 7/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
08having 12 to 20 amino acids
Applicants
  • KINETA CHRONIC PAIN, LLC [US]/[US]
Inventors
  • MERCADO, Jose
  • TARCHA, Eric, J.
  • POSAKONY, Jeffrey, J.
  • IADONATO, Shawn
Agents
  • ANTLER, Adriane, M.
  • ROWAN, Thomas, G.
  • SHENTOV, Ognjan, V.
  • ANTLER, Adriane, M.
  • GEORGE, Nikolaos, C.
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CONOTOXIN PEPTIDE ANALOGS AND USES FOR THE TREATMENT OF PAIN AND INFLAMMATORY CONDITIONS
(FR) ANALOGUES PEPTIDIQUES DE CONOTOXINE ET LEURS UTILISATIONS POUR LE TRAITEMENT DE LA DOULEUR ET D'AFFECTIONS INFLAMMATOIRES
Abstract
(EN)
Provided herein are alpha-conotoxin peptide analogs, including alpha-conotoxin peptide analogs that are covalently attached to polyethylene glycol (PEG), and pharmaceutical compositions of such alpha-conotoxin peptide analogs. Also provided herein are methods of treating or preventing a condition conducive to treatment or prevention by inhibition of an a9- containing nicotinic acetylcholine receptor (nAChR) (e.g., the α9α10 subtype of the nAChR) in a subject.
(FR)
La présente invention concerne des analogues peptidiques d'alpha-conotoxine, notamment des analogues peptidiques d'alpha-conotoxine qui sont liés de manière covalente au polyéthylène glycol (PEG), et des compositions pharmaceutiques de tels analogues peptidiques d'alpha-conotoxine. L'invention concerne également des méthodes de traitement ou de prévention d'une affection favorable au traitement ou à la prévention par inhibition d'un récepteur nicotinique de l'acétylcholine (nAChR) contenant a9 (par exemple, le sous-type α9α10 du nAChR) chez un sujet.
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