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1. WO2020141974 - TRUNCATED MULTIVALENT MULTIMERS

Publication Number WO/2020/141974
Publication Date 09.07.2020
International Application No. PCT/NL2019/050880
International Filing Date 30.12.2019
IPC
C07K 16/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
CPC
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K 2317/31
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
31multispecific
C07K 2317/35
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
35Valency
C07K 2317/53
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
52Constant or Fc region; Isotype
53Hinge
C07K 2317/54
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
54F(ab')2
C07K 2317/55
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
55Fab or Fab'
Applicants
  • MERUS N.V. [NL]/[NL]
Inventors
  • DE KRUIF, Cornelis Adriaan
Agents
  • WITMANS, H. A.
Priority Data
62/786,80631.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TRUNCATED MULTIVALENT MULTIMERS
(FR) MULTIMÈRES MULTIVALENTS TRONQUÉS
Abstract
(EN)
The invention relates to a truncated multivalent multimer comprising two or more binding domains, wherein each binding domain binds a different antigen or epitope, and wherein two of said binding domains are paired via a hinge region, wherein the multimer lacks a CH2 or CH3 region. The present invention further comprises two polypeptides that are paired at or near their respective C-terminus comprising two or more disulfide bridges, wherein each of said polypeptide comprise a variable binding domain, comprising a variable region, wherein each variable region binds the same or different antigens or epitopes on an antigen.
(FR)
L'invention concerne un multimère multivalent tronqué comprenant au moins deux domaines de liaison, chaque domaine de liaison se liant à un antigène ou à un épitope différent, et deux desdits domaines de liaison étant appariés par l'intermédiaire d'une région charnière, le multimère étant dépourvu d'une région CH2 ou CH3. La présente invention concerne en outre deux polypeptides appariés au niveau ou à proximité de leur extrémité C-terminale respective comprenant deux ponts disulfure ou plus, chacun desdits polypeptides comprenant un domaine de liaison variable, comprenant une région variable, chaque région variable liant les mêmes antigènes ou épitopes identiques ou différents sur un antigène.
Also published as
EA202191242
IL283701
Latest bibliographic data on file with the International Bureau