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1. WO2020141930 - DRUG DELIVERY SYSTEM USING PH-DEPENDENT CELL-PENETRATING PEPTIDES, AND COMPOSITE THEREOF WITH DRUG

Publication Number WO/2020/141930
Publication Date 09.07.2020
International Application No. PCT/KR2020/000116
International Filing Date 03.01.2020
IPC
A61K 47/64 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K 47/68 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A61K 47/56 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
A61K 45/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 49/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
CPC
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 47/56
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
A61K 47/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K 47/68
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A61K 49/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 김성천 KIM, Sung Chun [KR]/[KR]
Inventors
  • 김성천 KIM, Sung Chun
Agents
  • 특허법인 태웅 TW INTERNATIONAL PATENT AND LAW FIRM
Priority Data
10-2019-000083603.01.2019KR
10-2019-009936414.08.2019KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) DRUG DELIVERY SYSTEM USING PH-DEPENDENT CELL-PENETRATING PEPTIDES, AND COMPOSITE THEREOF WITH DRUG
(FR) SYSTÈME D'ADMINISTRATION DE MÉDICAMENT UTILISANT DES PEPTIDES DE PÉNÉTRATION CELLULAIRE DÉPENDANT DU PH, ET COMPOSITE DE CEUX-CI AVEC UN MÉDICAMENT
(KO) 피에이치 의존적 막 투과성 펩타이드를 이용한 약물 운반체 및 그것과 약물의 복합체
Abstract
(EN)
The present invention provides a drug delivery system using pH-dependent cell-penetrating peptides, and a composite thereof with a drug. The drug delivery system of the present invention acts selectively (or specifically) only on a specific target cell to thereby mitigate drug side effects and enhance drug efficacy, and may be useful as a drug delivery system of anticancer drugs, immunosuppressants, contrast agents, and the like.
(FR)
La présente invention concerne un système d'administration de médicament utilisant des peptides de pénétration cellulaire dépendant du pH, et un composite de ceux-ci avec un médicament. Le système d'administration de médicament de la présente invention agit sélectivement (ou spécifiquement) uniquement sur une cellule cible spécifique pour ainsi atténuer les effets secondaires du médicament et améliorer l'efficacité du médicament, et peut être utile en tant que système d'administration de médicaments tels que des médicaments anticancéreux, des immunosuppresseurs, des agents de contraste et analogues.
(KO)
본 발명은 pH 의존적 막 투과성 펩타이드를 이용한 약물 운반체 및 그것과 약물의 복합체를 제공한다. 본 발명의 약물 운반체는 특정 표적세포에만 선택적으로(또는 특이적으로) 작용함으로써 약물 부작용은 경감되고 약물의 약효는 증대시킬 수 있는 효과를 가지며 항암제, 면역 억제제, 조영제 등의 약물 운반체로서 유용하게 사용될 수 있다.
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