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1. WO2020141893 - ANTIBODY-BOUND NANOWIRE FOR EXOSOME SEPARATION, AND EXOSOME SEPARATION METHOD USING SAME

Publication Number WO/2020/141893
Publication Date 09.07.2020
International Application No. PCT/KR2020/000038
International Filing Date 02.01.2020
IPC
G01N 33/543 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
G01N 33/545 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
544the carrier being organic
545Synthetic resin
G01N 33/574 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
CPC
G01N 33/543
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
G01N 33/545
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
544the carrier being organic
545Synthetic resin
G01N 33/574
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
Applicants
  • 주식회사 제놉시 GENOPSY CO., LTD. [KR]/[KR]
Inventors
  • 조영남 CHO, Youngnam
Agents
  • 류종우 RYU, Jong Woo
Priority Data
10-2019-000068003.01.2019KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) ANTIBODY-BOUND NANOWIRE FOR EXOSOME SEPARATION, AND EXOSOME SEPARATION METHOD USING SAME
(FR) NANOFIL LIÉ À UN ANTICORPS POUR LA SÉPARATION D'EXOSOMES, ET PROCÉDÉ DE SÉPARATION D'EXOSOMES L'UTILISANT
(KO) 항체가 결합된 엑소좀 분리용 나노와이어 및 이를 이용한 엑소좀 분리 방법
Abstract
(EN)
The present invention relates to an antibody-bound nanowire for exosome separation, and an exosome separation method using same. By using an antibody-bound nanowire for exosome separation, according to the present invention, circulating exosomes having a diameter of 40 nm to 150 nm have been separated from a small amount of a sample within 1 hour in a high yield. In addition, it has been confirmed that the amount of circulating exosomes detected in a sample obtained from a cancer patient is 3 times greater than that of a normal person. Therefore, an antibody-bound nanowire for exosome separation, and the exosome separation method using same, of the present invention, can be effectively used in cancer diagnosis or prognosis prediction.
(FR)
La présente invention concerne un nanofil lié à un anticorps pour la séparation d'exosomes, et un procédé de séparation d'exosomes l'utilisant. En utilisant un nanofil lié à un anticorps pour la séparation d'exosomes, selon la présente invention, des exosomes circulants ayant un diamètre de 40 nm à 150 nm ont été séparés d'une petite quantité d'un échantillon en 1 heure à un rendement élevé. De plus, il a été confirmé que la quantité d'exosomes circulants détectés dans un échantillon prélevé chez un patient cancéreux est 3 fois supérieure à celle d'une personne normale. Par conséquent, un nanofil lié à un anticorps pour la séparation d'exosomes, et le procédé de séparation d'exosomes l'utilisant, selon la présente invention, peuvent être efficacement utilisés dans le diagnostic ou la prédiction de pronostic du cancer.
(KO)
본 발명은 항체가 결합된 엑소좀 분리용 나노와이어 및 이를 이용한 엑소좀 분리 방법에 관한 것이다. 본 발명에 따른 항체가 결합된 엑소좀 분리용 나노와이어를 이용하여 소량의 시료로부터 40 nm 내지 150 nm 직경의 순환 엑소좀을 높은 수율로 1시간 내에 분리하였다. 또한, 암 환자로부터 수득한 시료에서 검출되는 순환 엑소좀의 양이 암 환자가 정상인보다 3배 이상 많은 것을 확인하였다. 따라서, 본 발명의 항체가 결합된 엑소좀 분리용 나노와이어 및 이를 이용한 엑소좀 분리방법은 암 진단 또는 예후 예측에 유용하게 사용될 수 있다.
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