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1. WO2020141552 - POTENT SYNERGISTIC COMPOSITIONS OF VASOACTIVE MEDIATORS ENHANCERS FOR IMPROVING VASCULAR ENDOTHELIAL FUNCTION

Publication Number WO/2020/141552
Publication Date 09.07.2020
International Application No. PCT/IN2020/050004
International Filing Date 02.01.2020
IPC
A61K 31/455 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
455Nicotinic acid, i.e. niacin; Derivatives thereof, e.g. esters, amides
A61K 31/5585 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
557Eicosanoids, e.g. leukotrienes
558having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
5585having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
A61K 36/21 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
A61P 3/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
06Antihyperlipidemics
A61P 3/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
CPC
A61K 31/455
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
455Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
A61K 31/5585
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
557Eicosanoids, e.g. leukotrienes ; or prostaglandins
558having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
5585having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
A61K 33/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
A61K 36/21
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
A61K 9/0056
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
Applicants
  • CELAGENEX RESEARCH (INDIA) PVT. LTD. [IN]/[IN]
Inventors
  • DHAMANE, Dhiraj
  • T., Rajendra Prasad
Agents
  • SINGH, Manisha
Priority Data
20192100009302.01.2019IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) POTENT SYNERGISTIC COMPOSITIONS OF VASOACTIVE MEDIATORS ENHANCERS FOR IMPROVING VASCULAR ENDOTHELIAL FUNCTION
(FR) COMPOSITIONS SYNERGIQUES PUISSANTES DE MÉDIATEURS VASOACTIFS FAVORISANT LA FONCTION ENDOTHÉLIALE VASCULAIRE
Abstract
(EN)
The present invention herein discloses potent synergistic compositions of vasoactive mediators enhancers for improving vascular endothelial function. Particularly, the invention relates to synergistic nutritional composition comprising exogenous blend of N1-methyl nicotinamide chloride and standardized red spinach extract enriched with nitrate content along with pharmaceutically acceptable excipients, wherein N1-methyl nicotinamide salt and standardized red spinach extract enriched with nitrate content are present in the ratio of 1: 0.5 to 1: 8; and N1-methyl nicotinamide chloride and nitrate of standardized red spinach extract, are present in the ratio of 1: 0.1 to 1: 1. The present synergistic composition is useful for treating endothelial dysfunction such as hypertension, atherosclerosis, thrombosis, myocardial infarction, heart injury.
(FR)
La présente invention concerne des compositions synergiques puissantes de médiateurs vasoactifs favorisant la fonction endothéliale vasculaire. En particulier, l'invention concerne une composition nutritionnelle synergique comprenant un mélange exogène de chlorure de N1-méthyl-nicotinamide et d'extrait d'épinard rouge standardisé enrichi en nitrate ainsi que des excipients pharmaceutiquement acceptables, où N1-méthyl-nicotinamide et l'extrait d'épinard rouge standardisé enrichi en nitrate sont présents dans une proportion allant de 1 : 0,5 à 1 : 8 ; et le chlorure de N1-méthyl-nicotinamide et le nitrate de l'extrait d'épinard rouge standardisé sont présents dans une proportion allant de 1 : 0,1 à 1 : 1. La présente composition synergique est utile pour traiter un dysfonctionnement endothélial tel que l'hypertension, l'athérosclérose, la thrombose, l'infarctus du myocarde et la lésion cardiaque.
Also published as
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