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1. WO2020141177 - LIQUID NICOTINE FORMULATION COMPRISING WATER-IMMISCIBLE SOLVENTS

Publication Number WO/2020/141177
Publication Date 09.07.2020
International Application No. PCT/EP2019/087195
International Filing Date 31.12.2019
IPC
A24B 15/16 2020.1
AHUMAN NECESSITIES
24TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
BMANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
15Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
10Chemical features of tobacco products or tobacco substitutes
16of tobacco substitutes
A24F 47/00 2020.1
AHUMAN NECESSITIES
24TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
FSMOKERS’ REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
47Smokers’ requisites not otherwise provided for
CPC
A24B 15/167
AHUMAN NECESSITIES
24TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
BMANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
15Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
10Chemical features of tobacco products or tobacco substitutes
16of tobacco substitutes
167in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
A24B 15/28
AHUMAN NECESSITIES
24TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
BMANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
15Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
18Treatment of tobacco products or tobacco substitutes
28by chemical substances
A61K 31/465
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
465Nicotine; Derivatives thereof
A61K 9/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
12Aerosols; Foams
Applicants
  • PHILIP MORRIS PRODUCTS S.A. [CH]/[CH]
Inventors
  • EMMETT, Robert
  • SCHALLER, Jean-Pierre
  • VUARNOZ-BIZE, Aline
Agents
  • MILLBURN, Julie
Priority Data
18215964.031.12.2018EP
18215966.531.12.2018EP
18215969.931.12.2018EP
18215976.431.12.2018EP
18215983.031.12.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) LIQUID NICOTINE FORMULATION COMPRISING WATER-IMMISCIBLE SOLVENTS
(FR) PRÉPARATION DE NICOTINE LIQUIDE COMPRENANT DES SOLVANTS NON MISCIBLES À L'EAU
Abstract
(EN)
A liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: at least one of water and one or more water-miscible solvents; one or more partially water-soluble, water-immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water- immiscible solvents having a water solubility at 20°C of less than or equal to about 5 mg/ml, wherein the liquid nicotine formulation has a water-insoluble, water-immiscible solvent content of greater than or equal to about 2 percent by weight. A liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: at least one of water and one or more water-miscible solvents; one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5, wherein the liquid nicotine formulation has a water-insoluble, water- immiscible solvent content of greater than or equal to about 2 percent by weight. A cartridge for use in an aerosol-generating system, the cartridge containing the liquid nicotine formulation. An aerosol-generating system comprising the liquid nicotine formulation and an atomiser configured to generate an aerosol from the liquid nicotine formulation.
(FR)
L'invention concerne une préparation de nicotine liquide destinée à être utilisée dans un système de génération d'aérosol, la préparation de nicotine liquide comprenant : de l'eau et/ou un ou plusieurs solvants miscibles à l'eau ; un ou plusieurs solvants partiellement hydrosolubles et non miscibles à l'eau ayant une hydrosolubilité à 20 °C comprise entre environ 20 mg/ml et environ 100 mg/ml ; et un ou plusieurs solvants non hydrosolubles et non miscibles à l'eau ayant une hydrosolubilité à 20 °C inférieure ou égale à environ 5 mg/ml, la préparation de nicotine liquide ayant une teneur en solvant non hydrosoluble et non miscible à l'eau supérieure ou égale à environ 2 pour cent en poids. L'invention concerne une préparation de nicotine liquide destinée à être utilisée dans un système de génération d'aérosol, la préparation de nicotine liquide comprenant : de l'eau et/ou un ou plusieurs solvants miscibles à l'eau ; un ou plusieurs solvants partiellement hydrosolubles et non miscibles à l'eau ayant un coefficient de partage (log P) à 20 °C compris entre environ 0,05 et environ 0,5 ; et un ou plusieurs solvants non hydrosolubles et non miscibles à l'eau ayant un coefficient de partage (log P) à 20 °C supérieur à environ 5, la préparation de nicotine liquide ayant une teneur en solvant non hydrosoluble et non miscible à l'eau supérieure ou égale à environ 2 pour cent en poids. L'invention concerne également une cartouche destinée à être utilisée dans un système de génération d'aérosol, la cartouche contenant la préparation liquide de nicotine. L'invention concerne également un système de génération d'aérosol comprenant la préparation de nicotine liquide et un atomiseur conçu pour générer un aérosol à partir de la préparation de nicotine liquide.
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