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1. WO2020141145 - ANTI-RABBIT CD19 ANTIBODIES AND METHODS OF USE

Publication Number WO/2020/141145
Publication Date 09.07.2020
International Application No. PCT/EP2019/087064
International Filing Date 27.12.2019
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
C07K 16/2803
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
C07K 2317/33
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
C07K 2317/565
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
56variable (Fv) region, i.e. VH and/or VL
565Complementarity determining region [CDR]
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH]/[CH] (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JO, JP, KE, KG, KH, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
  • HOFFMANN-LA ROCHE INC. [US]/[US] (US)
Inventors
  • HAAS, Alexander
  • JUNG, Friederike
  • KLOSTERMANN, Stefan
  • OFFNER, Sonja
Agents
  • SKOLAUT, Alexander
Priority Data
18215920.230.12.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTI-RABBIT CD19 ANTIBODIES AND METHODS OF USE
(FR) ANTICORPS ANTI-LAPIN CD19 ET PROCÉDÉS D'UTILISATION
Abstract
(EN)
Herein is reported an antibody binding to rabbit CD19 comprising (a) a HVR-H1 comprising the amino acid sequence of SEQ ID NO: 32 or 33 or 34, (b) a HVR-H2 comprising the amino acid sequence of SEQ ID NO: 35 or 36, (c) a HVR-H3 comprising the amino acid sequence of SEQ ID NO: 37, (d) a HVR-L1 comprising the amino acid sequence of SEQ ID NO: 38, (e) a HVR-L2 comprising the amino acid sequence of SEQ ID NO: 39, and (f) a HVR-L3 comprising the amino acid sequence of SEQ ID NO: 40, as well as methods of using the same, especially in the identification and selection of antibody producing rabbit B-cells.
(FR)
La présente invention concerne un anticorps se liant au CD19 de lapin comprenant (a) un HVR-H1 comprenant la séquence d'acides aminés de SEQ ID NO : 32 ou 33 ou 34, (b) un HVR-H2 comprenant la séquence d'acides aminés de SEQ ID NO : 35 ou 36, (c) un HVR-H3 comprenant la séquence d'acides aminés de SEQ ID NO : 37, (d) un HVR-L1 comprenant la séquence d'acides aminés de SEQ ID NO : 38, (e) un HVR-L2 comprenant la séquence d'acides aminés de SEQ ID NO : 39, et (f) un HVR-L3 comprenant la séquence d'acides aminés de SEQ ID NO : 40, ainsi que des procédés d'utilisation de ceux-ci, en particulier dans l'identification et la sélection d'anticorps produisant des lymphocytes B de lapin.
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