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1. WO2020141137 - CALIBRATING RADIOLOGICAL DATA BASED ON CELL DISTRIBUTION

Publication Number WO/2020/141137
Publication Date 09.07.2020
International Application No. PCT/EP2019/086998
International Filing Date 24.12.2019
IPC
A61B 6/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
6Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
A61B 6/03 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
6Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
02Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
03Computerised tomographs
G06T 7/00 2017.01
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
7Image analysis
G02B 21/36 2006.01
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
36arranged for photographic purposes or projection purposes
A61B 5/055 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
05Measuring for diagnosis by means of electric currents or magnetic fields
055involving electronic or nuclear magnetic resonance, e.g. magnetic resonance imaging
CPC
A61B 5/055
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
055involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
A61B 6/032
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
6Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
02Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
03Computerised tomographs
032Transmission computed tomography [CT]
A61B 6/037
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
6Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
02Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
03Computerised tomographs
037Emission tomography
A61B 6/5247
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
6Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
52Devices using data or image processing specially adapted for radiation diagnosis
5211involving processing of medical diagnostic data
5229combining image data of a patient, e.g. combining a functional image with an anatomical image
5247combining images from an ionising-radiation diagnostic technique and a non-ionising radiation diagnostic technique, e.g. X-ray and ultrasound
G02B 21/365
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
36arranged for photographic purposes or projection purposes
365Control or image processing arrangements for digital or video microscopes
Applicants
  • KONINKLIJKE PHILIPS N.V. [NL]/[NL]
Inventors
  • WIMBERGER-FRIEDL, Reinhold
  • VITTORINO DE ALMEIDA, Vanda Lucia De Carvalho
  • DA SILVA RODRIGUES, Pedro Jorge
Agents
  • PHILIPS INTELLECTUAL PROPERTY & STANDARDS
Priority Data
19150208.703.01.2019EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CALIBRATING RADIOLOGICAL DATA BASED ON CELL DISTRIBUTION
(FR) ÉTALONNAGE DE DONNÉES RADIOLOGIQUES BASÉ SUR LA DISTRIBUTION DE CELLULES
Abstract
(EN)
Methods and systems for calibrating radiological data associated with a tissue in a subject are provide. Various embodiments described herein analyze a radiological image of the tissue to calculate a raw value indicative of a biological parameter such as metabolic activity in the tissue, and analyze a microscopy image of the tissue to identify a distribution of cells of interest within the tissue. A calibrated value indicative of a biological parameter (e.g. metabolic activity) of cells of interest within the tissue is then calculated, by correcting the raw value based on the identified distribution of cells of interest within the tissue.
(FR)
La présente invention concerne des procédés et des systèmes d’étalonnage de données radiologiques associées à un tissu chez un sujet. Divers modes de réalisation décrits ci-inclus analysent une image radiologique du tissu pour calculer une valeur brute indicatrice d’un paramètre biologique tel que l’activité métabolique dans le tissu, et analyser une image microscopique du tissu pour identifier une distribution des cellules d’intérêt à l’intérieur du tissu. Une valeur d’étalonnage indicatrice d’un paramètre biologique (par exemple activité métabolique) de cellules d’intérêt à l’intérieur du tissu est ensuite calculée, en corrigeant la valeur brute basée sur la distribution identifiée des cellules d’intérêt à l’intérieur du tissu.
Also published as
Latest bibliographic data on file with the International Bureau