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1. WO2020140529 - PSEUDOPEPTIDE, PREPARATION METHOD THEREFOR, AND USES THEREOF

Publication Number WO/2020/140529
Publication Date 09.07.2020
International Application No. PCT/CN2019/110442
International Filing Date 10.10.2019
IPC
C07K 7/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
A61K 31/341 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
34having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
341not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
A61K 31/36 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
357having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
36Compounds containing methylenedioxyphenyl groups, e.g. sesamin
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
G01N 33/08 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
02Food
08Eggs, e.g. by candling
CPC
A61K 31/341
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
34having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
341not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
A61K 31/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
357having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
36Compounds containing methylenedioxyphenyl groups, e.g. sesamin
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
B01L 3/5027
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware
50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
502with fluid transport, e.g. in multi-compartment structures
5027by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
Applicants
  • 京东方科技集团股份有限公司 BOE TECHNOLOGY GROUP CO., LTD. [CN]/[CN]
  • 北京京东方技术开发有限公司 BEIJING BOE TECHNOLOGY DEVELOPMENT CO., LTD. [CN]/[CN]
Inventors
  • 赵子健 ZHAO, Zijian
Agents
  • 北京市柳沈律师事务所 LIU, SHEN & ASSOCIATES
Priority Data
201910005412.703.01.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) PSEUDOPEPTIDE, PREPARATION METHOD THEREFOR, AND USES THEREOF
(FR) PSEUDOPEPTIDE, SON PROCEDE DE PREPARATION ET SES APPLICATIONS
(ZH) 一种类肽及其制备方法和用途
Abstract
(EN)
Provided are a pseudopeptide, which is a compound of formula I, or a stereoisomer thereof, a mixture of stereoisomer or a pharmaceutically acceptable salt thereof. The N-R4, N-R3, N-R2 and N-R1 of formula I respectively represent a pseudopeptide (II) showing a strong ability to bind to an EGFR protein. The pseudopeptide can be at the same time a targeted therapy for diseases associated with EGFR protein and an imaging test or prognostic prediction for diseases associated with EGFR protein.
(FR)
L’invention concerne un pseudopeptide, qui est un composé de formule I, ou son stéréo-isomère, le mélange de ce dernier ou son sel pharmaceutiquement acceptable. Le N-R 4, N-R 3, N-R 2 et N-R 1 de formule I désigne respectivement un pseudopeptide (II) avec une forte aptitude à se fixer sur une protéine IGFR. Le pseudopeptide peut être à la fois un traitement ciblé pour des maladies associées à la protéine EGFR et un examen d’imagerie ou un pronostic de maladies associées à la protéine EGFR.
(ZH)
本公开的实施例提供一种类肽,其是式I的化合物或其立体异构体、立体异构体的混合物或者它们的可药用盐,在式I中的N-R4、N-R3、N-R2、N-R1分别为该类肽与EGFR蛋白的结合能力较强,其不但可用于靶向治疗与EGFR蛋白相关的疾病,还可用于成像检测或预后监测与EGFR蛋白相关的疾病。
Also published as
Latest bibliographic data on file with the International Bureau