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1. WO2020139977 - USE OF GLUCOCORTICOID STEROIDS IN PREVENTING AND TREATING CONDITIONS OF MUSCLE WASTING, AGING AND METABOLIC DISORDER

Publication Number WO/2020/139977
Publication Date 02.07.2020
International Application No. PCT/US2019/068618
International Filing Date 26.12.2019
IPC
A61K 31/33 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
A61P 21/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
CPC
A61K 31/33
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
Applicants
  • NORTHWESTERN UNIVERSITY [US]/[US]
Inventors
  • QUATTROCELLI, Mattia
  • DEMONBREUN, Alexis, R.
  • MCNALLY, Elizabeth, M.
Agents
  • ALLIKIAN, Michael, J.
  • MERKEL, William, K.
Priority Data
62/785,02926.12.2018US
62/876,23819.07.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) USE OF GLUCOCORTICOID STEROIDS IN PREVENTING AND TREATING CONDITIONS OF MUSCLE WASTING, AGING AND METABOLIC DISORDER
(FR) UTILISATION DE STÉROÏDES DE GLUCOCORTICOÏDES DANS LA PRÉVENTION ET LE TRAITEMENT DE L'ATROPHIE MUSCULAIRE, DU VIEILLISSEMENT ET DU TROUBLE MÉTABOLIQUE
Abstract
(EN)
Chronic glucocorticoid steroids produce muscle atrophy, but intermittent steroid exposure can promote muscle growth and function. It is disclosed herein that, in contrast to daily administration of a steroid, once-weekly steroid administration improved muscle mass and exercise tolerance in normal subjects as well as multiple models of muscle disease.
(FR)
Les stéroïdes glucocorticoïdes chroniques produisent une atrophie musculaire, mais l'exposition à des stéroïdes intermittente peut favoriser la croissance et la fonction musculaires. L'invention revèle que, contrairement à l'administration quotidienne d'un stéroïde, une administration de stéroïdes hebdomadaire améliore la masse musculaire et la tolérance à l'exercice chez des sujets normaux ainsi que dans de multiples modèles de maladies musculaires.
Latest bibliographic data on file with the International Bureau