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1. WO2020139932 - DEVICE, SYSTEM, AND METHOD FOR RAPID FIXATION AND EMBEDDING OF BIOLOGICAL SPECIMENS

Publication Number WO/2020/139932
Publication Date 02.07.2020
International Application No. PCT/US2019/068559
International Filing Date 26.12.2019
IPC
A01N 1/02 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
1Preservation of bodies of humans or animals, or parts thereof
02Preservation of living parts
G01N 1/28 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1Sampling; Preparing specimens for investigation
28Preparing specimens for investigation
G01N 1/30 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1Sampling; Preparing specimens for investigation
28Preparing specimens for investigation
30Staining; Impregnating
G01N 1/31 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1Sampling; Preparing specimens for investigation
28Preparing specimens for investigation
30Staining; Impregnating
31Apparatus therefor
G02B 21/34 2006.01
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
34Microscope slides, e.g. mounting specimens on microscope slides
CPC
G01N 1/30
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1Sampling; Preparing specimens for investigation
28Preparing specimens for investigation ; including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
30Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
G01N 1/31
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1Sampling; Preparing specimens for investigation
28Preparing specimens for investigation ; including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
30Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
31Apparatus therefor
G01N 1/36
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1Sampling; Preparing specimens for investigation
28Preparing specimens for investigation ; including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
36Embedding or analogous mounting of samples
G01N 2001/366
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1Sampling; Preparing specimens for investigation
28Preparing specimens for investigation ; including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
36Embedding or analogous mounting of samples
366Moulds; Demoulding
G02B 21/34
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
34Microscope slides, e.g. mounting specimens on microscope slides
Applicants
  • UNIVERSITY OF CINCINNATI [US]/[US]
Inventors
  • LEE, Paul
Agents
  • LIVINGSTON, Jennifer L.
  • LORENTZ, Joshua A.
  • SINGH, Ritu
  • CHOI, Yongsok
  • NEAL, Cynthia A.
  • OBERHAUS, Geoffrey L.
  • RERICHA, Nicholaus R.
  • TENT, Brian A.
  • BONNER, Anthony F.
Priority Data
62/784,95926.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DEVICE, SYSTEM, AND METHOD FOR RAPID FIXATION AND EMBEDDING OF BIOLOGICAL SPECIMENS
(FR) DISPOSITIF, SYSTÈME ET PROCÉDÉ DE FIXATION ET D'INCORPORATION RAPIDES D'ÉCHANTILLONS BIOLOGIQUES
Abstract
(EN)
Provided herein is a device for rapid fixation and embedding of a biological specimen, the device including a barrel having a first end and a second end, the first end receiving a plunger and the second end opening to a compartment defining a block mold; and a plunger for inserting in the barrel, the plunger having a first end, a second end, and an interior conduit connecting the first and second ends, wherein the first end of the plunger connects to a vacuum source and the second end of the plunger includes a filter barrier between the interior conduit of the plunger and a receptacle for receiving, fixing, and embedding the specimen, the receptacle defined inside the barrel when the plunger is disposed in the barrel. Also provided are a system and method for rapid fixation and embedding of a biological specimen.
(FR)
L'invention concerne un dispositif pour la fixation et l'incorporation rapides d'un échantillon biologique, le dispositif comprenant un cylindre ayant une première extrémité et une seconde extrémité, la première extrémité recevant un piston et la seconde extrémité débouchant dans un compartiment définissant un moule à blocs ; et un piston destiné à être inséré dans le cylindre, le piston ayant une première extrémité, une seconde extrémité, et un conduit intérieur reliant les première et seconde extrémités, la première extrémité du piston étant reliée à une source de vide et la seconde extrémité du piston comprenant une barrière de filtre entre le conduit intérieur du piston et un réceptacle pour recevoir, fixer et incorporer l'échantillon, le réceptacle étant défini à l'intérieur du cylindre lorsque le piston est disposé dans le cylindre. L'invention concerne également un système et un procédé de fixation et d'incorporation rapides d'un échantillon biologique.
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