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1. WO2020139873 - TOLLIP DEFICIENT NEUTROPHILS AND USES THEREOF

Publication Number WO/2020/139873
Publication Date 02.07.2020
International Application No. PCT/US2019/068443
International Filing Date 23.12.2019
IPC
A61K 35/12 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A61P 9/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
12Antihypertensives
CPC
A61K 35/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 9/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
12Antihypertensives
Applicants
  • VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY [US]/[US]
Inventors
  • LI, Liwu
  • ZHANG, Yao
  • LEE, Christina
Agents
  • MILLER, Carin R.
  • NIX, F. Brent
Priority Data
62/784,59524.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TOLLIP DEFICIENT NEUTROPHILS AND USES THEREOF
(FR) NEUTROPHILES CARANCÉS EN TOLLIP ET LEURS UTILISATIONS
Abstract
(EN)
Described herein are modified cells and compositions thereof, wherein the cells can have reduced or eliminated Tollip gene and/or protein expression. In some embodiments, the modified cells can be neutrophils. Also described herein are methods of making and using the modified cells and compositions thereof. In some embodiments, the modified cells having reduced or eliminated Tollip gene and/or protein expression can be administered to a subject in need thereof.
(FR)
L'invention concerne des cellules modifiées et leurs compositions, les cellules pouvant avoir une expression génique et/ou protéique de Tollip réduite ou supprimée. Selon certains modes de réalisation, les cellules modifiées peuvent être des neutrophiles. L'invention concerne également des méthodes de fabrication et d'utilisation des cellules modifiées et de leurs compositions. Selon certains modes de réalisation, les cellules modifiées ayant une expression génique et/ou protéique de Tollip réduite ou supprimée peuvent être administrées à un sujet en ayant besoin.
Latest bibliographic data on file with the International Bureau