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1. WO2020139852 - COMBINATIONS OF ENGINEERED ANTIMICROBIAL PROBIOTICS FOR TREATMENT OF GASTROINTESTINAL TRACT PATHOGENS

Publication Number WO/2020/139852
Publication Date 02.07.2020
International Application No. PCT/US2019/068400
International Filing Date 23.12.2019
IPC
A61K 35/741 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
C12N 1/20 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
20Bacteria; Culture media therefor
A23K 10/16 2016.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
KFEEDING-STUFFS SPECIALLY ADAPTED FOR ANIMALS; METHODS SPECIALLY ADAPTED FOR PRODUCTION THEREOF
10Animal feeding-stuffs
10obtained by microbiological or biochemical processes
16Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
A23K 50/70 2016.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
KFEEDING-STUFFS SPECIALLY ADAPTED FOR ANIMALS; METHODS SPECIALLY ADAPTED FOR PRODUCTION THEREOF
50Feeding-stuffs specially adapted for particular animals
70for birds
A23L 33/135 2016.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
135Bacteria or derivatives thereof, e.g. probiotics
A61K 35/742 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
742Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
CPC
A23K 10/16
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
KFODDER
10Animal feeding-stuffs
10obtained by microbiological or biochemical processes
16Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
A23K 50/70
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
KFODDER
50Feeding-stuffs specially adapted for particular animals
70for birds
A23L 33/135
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
135Bacteria or derivatives thereof, e.g. probiotics
A61K 35/741
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
A61K 35/742
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
742Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
A61K 35/747
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
747Lactobacilli, e.g. L. acidophilus or L. brevis
Applicants
  • GENERAL PROBIOTICS, INC. [US]/[US]
Inventors
  • KAZNESSIS, Yiannis John
  • KRUZIKI, Kathryn Gayle
  • SIDIROPOULOS, Dimitrios Nikolaos
Agents
  • DEFFNER, Mark E.
  • DEVRIES SMITH, Katherine M.
Priority Data
62/785,95428.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMBINATIONS OF ENGINEERED ANTIMICROBIAL PROBIOTICS FOR TREATMENT OF GASTROINTESTINAL TRACT PATHOGENS
(FR) COMBINAISONS DE PROBIOTIQUES ANTIMICROBIENS MODIFIÉS POUR LE TRAITEMENT D'AGENTS PATHOGÈNES DU TRACTUS GASTRO-INTESTINAL
Abstract
(EN)
Embodiments herein relate to engineered antimicrobial probiotics for the treatment of gastrointestinal tract pathogens. In an embodiment, a composition for treatment of an animal is included. The composition can include a first genetically engineered bacterium comprising a first exogenous polynucleotide. The first exogenous polynucleotide can include a first heterologous promoter and a first polynucleotide that encodes a first antimicrobial protein. The composition can also include a second genetically engineered bacterium comprising a second exogenous polynucleotide. The second exogenous polynucleotide can include a second heterologous promoter and a second polynucleotide that encodes a second antimicrobial protein. The first heterologous promoter can be induced by one set of exogenous environmental conditions found in the gastrointestinal tract of the animal and the second heterologous promoter can be induced by a second set of exogenous environmental conditions found in the gastrointestinal tract of the animal. Other embodiments are also included herein.
(FR)
Des modes de réalisation de la présente invention concernent des probiotiques antimicrobiens modifiés pour le traitement d'agents pathogènes du tractus gastro-intestinal. Dans un mode de réalisation, l'invention concerne une composition pour le traitement d'un animal. La composition peut comprendre une première bactérie génétiquement modifiée comprenant un premier polynucléotide exogène. Le premier polynucléotide exogène peut comprendre un premier promoteur hétérologue et un premier polynucléotide qui code une première protéine antimicrobienne. La composition peut également comprendre une seconde bactérie génétiquement modifiée comprenant un second polynucléotide exogène. Le second polynucléotide exogène peut comprendre un second promoteur hétérologue et un second polynucléotide qui code une seconde protéine antimicrobienne. Le premier promoteur hétérologue peut être induit par un ensemble de conditions environnementales exogènes trouvées dans le tractus gastro-intestinal de l'animal, et le second promoteur hétérologue peut être induit par un second ensemble de conditions environnementales exogènes trouvées dans le tractus gastro-intestinal de l'animal. D'autres modes de réalisation sont également inclus ici.
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