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1. WO2020139844 - DEVICES, SYSTEMS, AND METHODS FOR CONTROLLING LIQUID FLOW

Publication Number WO/2020/139844
Publication Date 02.07.2020
International Application No. PCT/US2019/068374
International Filing Date 23.12.2019
IPC
B01L 3/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B01F 3/08 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
3Mixing, e.g. dispersing, emulsifying, according to the phases to be mixed
08liquids with liquids; Emulsifying
B01F 13/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
13Other mixers; Mixing plant, including combinations of dissimilar mixers
B05B 12/10 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
05SPRAYING OR ATOMISING IN GENERAL; APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL
BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
12Arrangements for controlling delivery; Arrangements for controlling the spray area
08responsive to condition of liquid or other fluent material discharged, of ambient medium or of target
10responsive to temperature or viscosity of liquid or other fluent material discharged
G01N 15/14 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
10Investigating individual particles
14Electro-optical investigation
CPC
B01F 13/0059
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
13Other mixers; Mixing plant, including combinations of ; mixers, e.g. of; dissimilar mixers
0059Micromixers
B01F 2005/0623
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
5Flow mixers
06Mixers in which the components are pressed together through slits, orifices, or screens; ; Static mixers; Mixers of the fractal type
0602Static mixers, i.e. mixers in which the mixing is effected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
0609Mixing tubes, e.g. the material being submitted to a substantially radial movement or to a movement partially in reverse direction
061Straight mixing tubes, e.g. with smooth walls, having baffles or obstructions therein without substantial pressure drop; Baffles therefor
062characterised by the configuration of the baffles or obstructions
0621Profiled elements, e.g. profiled blades, bars, pillars, columns or chevrons
0623Profiles, pillars, chevrons, i.e. long elements having a polygonal cross-section
B01F 2005/0636
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
5Flow mixers
06Mixers in which the components are pressed together through slits, orifices, or screens; ; Static mixers; Mixers of the fractal type
0602Static mixers, i.e. mixers in which the mixing is effected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
0609Mixing tubes, e.g. the material being submitted to a substantially radial movement or to a movement partially in reverse direction
061Straight mixing tubes, e.g. with smooth walls, having baffles or obstructions therein without substantial pressure drop; Baffles therefor
0635characterised by the mounting of the baffles or obstructions
0636Mounted on the wall
B01F 5/061
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
5Flow mixers
06Mixers in which the components are pressed together through slits, orifices, or screens; ; Static mixers; Mixers of the fractal type
0602Static mixers, i.e. mixers in which the mixing is effected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
0609Mixing tubes, e.g. the material being submitted to a substantially radial movement or to a movement partially in reverse direction
061Straight mixing tubes, e.g. with smooth walls, having baffles or obstructions therein without substantial pressure drop; Baffles therefor
B01F 5/0647
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
5Flow mixers
06Mixers in which the components are pressed together through slits, orifices, or screens; ; Static mixers; Mixers of the fractal type
0602Static mixers, i.e. mixers in which the mixing is effected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
0609Mixing tubes, e.g. the material being submitted to a substantially radial movement or to a movement partially in reverse direction
0646Mixers composed of several consecutive mixing tubes; Mixing tubes being deformed or bent, e.g. having varying cross-section or being provided with inwardly extending profiles, e.g. with internal screw-thread profile
0647Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
B01L 2200/0647
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
06Fluid handling related problems
0647Handling flowable solids, e.g. microscopic beads, cells, particles
Applicants
  • 10X GENOMICS, INC. [US]/[US]
Inventors
  • AKHREMICHEV, Ivan
  • BHARADWAJ, Rajiv
  • CHEN, Lynna
  • CUI, Francis
  • GERVER, Rachel
  • LENJI, Mohammad, Rahimi
  • LIN, Bill, Kengli
  • MAKAREWICZ, Anthony
  • SAUZADE, Martin
  • TANNA, Astha
  • VALDECANAS, Fernandino
  • WHEELER, Tobias, Daniel
  • ZHANG, Yiran
  • SALMANZADEH, Alireza
Agents
  • MCDONALD, J., Cooper
Priority Data
62/784,64224.12.2018US
62/811,57128.02.2019US
62/811,82328.02.2019US
62/811,87128.02.2019US
62/811,99228.02.2019US
62/853,69828.05.2019US
62/868,62428.06.2019US
PCT/US2019/06573511.12.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DEVICES, SYSTEMS, AND METHODS FOR CONTROLLING LIQUID FLOW
(FR) DISPOSITIFS, SYSTÈMES ET PROCÉDÉS DE COMMANDE D'UN ÉCOULEMENT DE LIQUIDE
Abstract
(EN)
Disclosed are devices, systems, kits, and methods for controlling liquid flow and, e.g., in particular, for forming droplet having substantially uniform droplet-to-droplet content. The devices, systems, and kits may include a first channel including a funnel or may include a first channel and a first-side channel, the first channel being in fluid communication with a droplet formation region. The devices, systems, and kits may further include a second channel fluidically connected to the first channel or the first side-channel. Funnels and/or side-channels may be used to enhance the control over particle spacing in the channels, thereby providing superior control over the number of particles of the same kind in formed droplets. The devices, systems, and kits of the invention may further include a mixer downstream of a channel intersection. Mixers can be used to reduce localized pockets of high concentration of dissolved ingredients.
(FR)
L'invention concerne des dispositifs, des systèmes, des kits et des procédés pour commander un écoulement de liquide et, par exemple, en particulier, pour former une gouttelette ayant un contenu de gouttelette à gouttelette sensiblement uniforme. Les dispositifs, les systèmes et les kits peuvent comprendre un premier canal comprenant un entonnoir ou peuvent comprendre un premier canal et un canal de premier côté, le premier canal étant en communication fluidique avec une région de formation de gouttelettes. Les dispositifs, les systèmes et les kits peuvent en outre comprendre un second canal en communication fluidique avec le premier canal ou le premier canal latéral. Des entonnoirs et/ou des canaux latéraux peuvent être utilisés pour améliorer la commande de l'espacement des particules dans les canaux, ce qui confère une meilleure commande du nombre de particules de même type dans des gouttelettes formées. Les dispositifs, les systèmes et les kits de l'invention peuvent en outre comprendre un mélangeur en aval d'une intersection de canaux. Des mélangeurs peuvent être utilisés pour réduire des poches localisées de concentration élevée d'ingrédients dissous.
Latest bibliographic data on file with the International Bureau