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1. WO2020139803 - BENZOTHIADIAZINE DERIVATIVES AND COMPOSITIONS COMPRISING THE SAME FOR TREATING DISORDERS MEDIATED BY ADENOSINE

Publication Number WO/2020/139803
Publication Date 02.07.2020
International Application No. PCT/US2019/068247
International Filing Date 23.12.2019
IPC
A61K 31/519 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
C07D 498/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
C07D 498/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • DCB-USA LLC [US]/[US]
  • DEVELOPMENT CENTER FOR BIOTECHNOLOGY [CN]/[CN]
Inventors
  • LAI LEE, Ying-Shuan
  • SUN, Wei-Ting
  • KUO, Mann-Yan
Agents
  • TSAO, Y., Rocky
Priority Data
62/784,55724.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BENZOTHIADIAZINE DERIVATIVES AND COMPOSITIONS COMPRISING THE SAME FOR TREATING DISORDERS MEDIATED BY ADENOSINE
(FR) DÉRIVÉS DE BENZOTHIADIAZINE ET COMPOSITIONS LES COMPRENANT POUR TRAITER DES TROUBLES MÉDIÉS PAR L'ADÉNOSINE
Abstract
(EN)
Disclosed herein are novel inhibitors of CD73. More specifically, the novel CD73 inhibitors are derived from benzothiadiazine. Further, the present disclosure is related to the use of said benzothiadiazine derivatives in the treatment of diseases and/or disorders mediated by adenosine, such as AIDS, an autoimmune disease, atherosclerosis, a cancer, an infectious disease, ischemia-reperfusion injury and pre-cancerous syndrome. Also encompassed in the present disclosure are pharmaceutical compositions comprising said benzothiadiazine derivatives.
(FR)
L'invention concerne de nouveaux inhibiteurs de CD73. Plus spécifiquement, les nouveaux inhibiteurs de CD73 sont dérivés de benzothiadiazine. En outre, la présente invention concerne l'utilisation desdits dérivés de benzothiadiazine dans le traitement de maladies et/ou de troubles médiés par l'adénosine, tels que le SIDA, une maladie auto-immune, l'athérosclérose, un cancer, une maladie infectieuse, une lésion d'ischémie-reperfusion et un syndrome précancéreux. La présente invention concerne également des compositions pharmaceutiques comprenant lesdits dérivés de benzothiadiazine.
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