Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020139430 - QUANTITATIVE LARGE AREA BINDING SENSOR FOR DETECTING BIOMARKERS

Publication Number WO/2020/139430
Publication Date 02.07.2020
International Application No. PCT/US2019/053530
International Filing Date 27.09.2019
IPC
G01N 15/14 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
10Investigating individual particles
14Electro-optical investigation
G01N 33/543 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
CPC
G01N 15/1434
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
10Investigating individual particles
14Electro-optical investigation, e.g. flow cytometers
1434using an analyser being characterised by its optical arrangement
G01N 15/1475
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
10Investigating individual particles
14Electro-optical investigation, e.g. flow cytometers
1468with spatial resolution of the texture or inner structure of the particle
1475using image analysis for extracting features of the particle
G01N 15/1484
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
10Investigating individual particles
14Electro-optical investigation, e.g. flow cytometers
1484microstructural devices
G01N 2015/0038
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
0038Investigating nanoparticles
G01N 2015/0092
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
0092Monitoring flocculation or agglomeration
G01N 2015/1006
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
10Investigating individual particles
1006for cytology
Applicants
  • ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA [US]/[US]
Inventors
  • XIONG, Zhen
  • MCLEOD, Euan
Agents
  • PHILLIPS, Erin, S.
  • NOCILLY, David, L.
  • NOTO, Joseph, M.
  • PRICE, Frederick, Jm
  • MCGUIRE, George
Priority Data
62/738,60228.09.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) QUANTITATIVE LARGE AREA BINDING SENSOR FOR DETECTING BIOMARKERS
(FR) CAPTEUR DE LIAISON QUANTITATIF À GRANDE SURFACE POUR LA DÉTECTION DE BIOMARQUEURS
Abstract
(EN)
An imaging system and method for detecting a target in a sample. The imaging system includes a lens-free holographic microscope having a light source in a first plane spaced above an image sensor. The image sensor extends in a second plane. The system also includes a microfluidic chip positioned between the light source and the image sensor. The microfluidic chip extends in a third plane, which is parallel to the second plane. There is at least one chamber in the microfluidic chip configured to receive a sample solution with a target. The system also has a plurality of functionalized beads positioned within the at least one chamber in the microfluidic chip. Any two of the plurality of functionalized beads have an affinity for binding together when exposed to the target in the sample solution.
(FR)
La présente invention concerne un système d'imagerie et un procédé de détection d'une cible dans un échantillon. Le système d'imagerie comprend un microscope holographique sans lentille comportant une source de lumière dans un premier plan espacé au-dessus d'un capteur d'image. Le capteur d'image s'étend dans un deuxième plan. Le système comprend également une puce microfluidique positionnée entre la source de lumière et le capteur d'image. La puce microfluidique s'étend dans un troisième plan, qui est parallèle au deuxième plan. Il existe au moins une chambre dans la puce microfluidique conçue pour recevoir une solution d'échantillon comportant une cible. Le système comprend également une pluralité de billes fonctionnalisées positionnées à l'intérieur de ladite chambre dans la puce microfluidique. Deux billes fonctionnalisées quelconques parmi la pluralité de billes fonctionnalisées ont une affinité pour se lier ensemble lorsqu'elles sont exposées à la cible dans la solution d'échantillon.
Latest bibliographic data on file with the International Bureau