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1. WO2020139163 - COMBINATION OF ANTIVIRAL AGENTS

Publication Number WO/2020/139163
Publication Date 02.07.2020
International Application No. PCT/RU2019/001031
International Filing Date 26.12.2019
IPC
A61K 31/7072 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7068having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
7072having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
A61K 31/513 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
513having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
A61P 31/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
CPC
A61K 31/513
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
513having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
A61K 31/7072
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7068having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
7072having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
A61P 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
Applicants
  • ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "ПРОЛОНГИРОВАННЫЕ ЛЕКАРСТВА" OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTYU "PROLONGIROVANNYE LEKARSTVA" [RU]/[RU]
Inventors
  • БИБИЛАШВИЛИ, Роберт Шалвович BIBILASHVILI, Robert Shalvovich
  • КОНОНОВ, Александр Васильевич KONONOV, Alexandr Vasilievich
  • КРАВЧЕНКО, Алексей Викторович KRAVCHENKO, Alexei Viktorovich
  • ХАНДАЖИНСКАЯ, Анастасия Львовна KHANDAZHINSKAYA, Anastasia Lvovna
  • СИМОНЯН, Алина Руслановна SIMONYAN, Alina Ruslanovna
Agents
  • МЕСЯШНАЯ, Наталия Витальевна MESYASHNAYA, Natalia Vitalievna
Priority Data
201814707827.12.2018RU
Publication Language Russian (RU)
Filing Language Russian (RU)
Designated States
Title
(EN) COMBINATION OF ANTIVIRAL AGENTS
(FR) COMBINAISON DE PRODUITS ANTIVIRAUX, ENSEMBLE ET MÉTHODE DE TRAITEMENT SUR LEUR BASE
(RU) КОМБИНАЦИЯ ПРОТИВОВИРУСНЫХ СРЕДСТВ
Abstract
(EN)
The group of inventions relates to the field of medicine and the pharmaceutical industry, and specifically to a combination for treatment of an HIV infection, comprising (i) an ammonia salt of 5-aminocarbonylphosphonate-3-azido-3-desoxythymidine and (ii) an analogue of cytidine selected from emtricitabine and lamivudine in a mass ratio of agent (i) to agent (ii) of from 250:1 to 1:250; to a kit which includes said combination and instructions for use thereof; and also to a method for treating an HIV infection in a mammal, including a human, by administering a therapeutically effective amount of the proposed combination to the mammal in need thereof. The group of inventions broadens the range of combined antiviral preparations for treating HIV infections and also increases the effectiveness of such treatment.
(FR)
Le groupe d'inventions se rapporte au domaine de la médecine et de l'industrie pharmaceutique et notamment à une combinaison pour le traitement de l'infection au VIH contenant (i) un sel ammoniaqué de 5-aminocarbonylphosphanate-3-azido-3-désoxythymidine et (ii) un analogue de cytidine sélection parmi emtricitabine et lamivudine, avec un rapport massique de l'agent (i) à l'agent (ii) de 250:1 et jusqu'à 1:250, un ensemble qui comprend la combinaison spécifiée et les instructions pour son utilisation; et également une méthode de traitement d'une infection par le VIH chez un mammifère, y compris un humain, en administrant à un mammifère qui en a besoin une quantité thérapeutiquement efficace d'une combinaison de l'invention. Le groupe d'inventions permet d'élargir la gamme de préparations antivirales combinées pour traiter l'infection au VIH et pour augmenter l'efficacité d'un tel traitement.
(RU)
Группа изобретений относится к области медицины и фармацевтической промышленности, а именно к комбинации для лечения ВИЧ-инфекции, содержащей (i) аммониевую соль 5-аминокарбонилфосфонат-3-азидо-3-дезокситимидина и (ii) аналог цитидина, выбранный из эмтрицитабина и ламивудина, при массовом соотношении агента (i) к агенту (ii) от 250:1 до 1:250; к набору, включающему указанную комбинацию и инструкцию по ее применению; а также к способу лечения ВИЧ-инфекции у млекопитающего, в том числе у человека, путем введения млекопитающему, нуждающемуся в этом, терапевтически эффективного количества предложенной комбинации. Группа изобретений обеспечивает расширение арсенала комбинированных противовирусных препаратов для лечения ВИЧ-инфекции, а также повышение эффективности такого лечения.
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Latest bibliographic data on file with the International Bureau