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1. WO2020139044 - NOVEL COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FOR ENHANCING ANTICANCER ACTIVITY

Publication Number WO/2020/139044
Publication Date 02.07.2020
International Application No. PCT/KR2019/018660
International Filing Date 27.12.2019
IPC
A61K 31/4985 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A61K 45/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/4985
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 홀로스메딕 주식회사 HOLOSMEDIC [KR]/[KR]
Inventors
  • 박기청 PARK, Ki Cheong
  • 정재호 CHEONG, Jae Ho
  • 김석모 KIM, Seok Mo
  • 윤여진 YUN, Yeo Jin
  • 김병모 KIM, Byeong Mo
Agents
  • 특허법인 서한 SEOHAN INTELLECTUAL PROPERTY LAW FIRM
Priority Data
10-2018-017084227.12.2018KR
10-2019-017670627.12.2019KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) NOVEL COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FOR ENHANCING ANTICANCER ACTIVITY
(FR) NOUVEAU COMPOSÉ ET COMPOSITION PHARMACEUTIQUE LE COMPRENANT POUR RENFORCER L'ACTIVITÉ ANTICANCÉREUSE
(KO) 신규한 화합물 및 이를 포함하는 항암 활성 증진용 약학 조성물
Abstract
(EN)
The present invention relates to a novel compound and a pharmaceutical composition comprising same for enhancing anticancer activity, and more specifically, by comprising a compound represented by chemical formula 1 or a pharmaceutically acceptable salt thereof, the anticancer activity of an anticancer agent or radiation can be enhanced, and by suppressing the proliferation of cancer cells and inducing apoptosis thereof, cancer can be treated effectively. [Chemical formula 1] In the chemical formula 1: n is an integer of 0 to 4; R1 is hydrogen, C1-C10 alkyl, or aryl(C1-C4)alkyl; R3 is C1-C6 alkyl, wherein the R3, if a plurality thereof is present, are identical or different from each other; L1 is a direct bond or C1-C6 alkylene; R2 is hydrogen, C1-C10 alkyl, or aryl(C1-C4)alkyl; and R4 is hydrogen, C1-C4 alkyl, C3-C8 cycloalkyl, or aryl(C1-C4)alkyl, or R2 and R4 are connected to each other, forming a 4- to 7-membered ring.
(FR)
La présente invention concerne un nouveau composé et une composition pharmaceutique le comprenant pour renforcer l'activité anticancéreuse, et plus spécifiquement, un composé représenté par la formule chimique 1 ou un sel pharmaceutiquement acceptable de celui-ci, qui permet de traiter efficacement le cancer en renforçant l'activité anticancéreuse d'un agent ou d'un rayonnement anticancéreux, en supprimant la prolifération de cellules cancéreuses et en induisant l'apoptose de celles-ci. [[Formule chimique 1] Dans la formule chimique 1 : n est un nombre entier de 0 à 4; R1 représente hydrogène, un alkyle en C1-C10 ou un arylalkyle en C1-C4; R3 représente un alkyle en C1-C6, les radicaux R3, si une pluralité de ceux-ci sont présents, étant identiques ou différents les uns des autres; L1 représente une liaison directe ou un alkylène en C1-C6; R2 représente un atome d'hydrogène, un alkyle en C1-C10 ou un arylalkyle en C1-C4; et R4 représente un atome d'hydrogène, un alkyle en C1-C4, un cycloalkyle en C3-C8 ou un arylalkyle en C1-C4, ou bien R2 et R4 sont liés l'un à l'autre et forment un cycle à 4 à 7 chaînons.
(KO)
본 발명은 신규한 화합물 및 이를 포함하는 항암 활성 증진용 약학 조성물에 관한 것으로, 보다 상세하게는 하기 화학식 1로 표시되는 화합물 또는 이의 약학적으로 허용 가능한 염을 포함함으로써, 항암제 또는 방사선의 항암 활성을 증진시킬 수 있으며, 암세포의 증식 억제 및 세포 사멸 등을 유도하여 효과적으로 암을 치료할 수 있다: [화학식 1] 상기 화학식 1에서, n은 0 내지 4의 정수이고; R 1은 수소, C1 내지 C10의 알킬 또는 아릴(C1 내지 C4)알킬이고; R 3은 C1 내지 C6의 알킬이고, 상기 R 3이 복수 개인 경우 이들은 서로 동일하거나 상이하며; L 1은 직접결합이거나 C1 내지 C6의 알킬렌이고; R 2는 수소, C1 내지 C10의 알킬 또는 아릴(C1 내지 C4)알킬이며, R 4는 수소, C1 내지 C4의 알킬, C3 내지 C8의 사이클로알킬 또는 아릴(C1 내지 C4)알킬이거나, R 2와 R 4가 4 내지 7원환을 이루며 서로 연결됨.
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Latest bibliographic data on file with the International Bureau