Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020139038 - CARRIER COMPLEX FOR EYE DROPS, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

Publication Number WO/2020/139038
Publication Date 02.07.2020
International Application No. PCT/KR2019/018642
International Filing Date 27.12.2019
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 9/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
06Ointments; Bases therefor
A61K 9/50 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
A61K 9/51 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
51Nanocapsules
A61K 47/69 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 31/573 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
57substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
573substituted in position 21, e.g. cortisone, dexamethasone, prednisone
CPC
A61K 31/573
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
57substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
573substituted in position 21, e.g. cortisone, dexamethasone, prednisone ; or aldosterone
A61K 47/69
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 9/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
06Ointments; Bases therefor; ; Other semi-solid forms, e.g. creams, sticks, gels
A61K 9/50
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
A61K 9/51
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
51Nanocapsules; Nanoparticles;
Applicants
  • 현대바이오사이언스 주식회사 HYUNDAIBIOSCIENCE CO., LTD. [KR]/[KR]
Inventors
  • 전용주 JUN, Young Joo
  • 김지현 KIM, Ji Hyun
  • 유병우 YOO, Byung Woo
  • 최지영 CHOI, Ji Young
Agents
  • 수안특허법인 SUAN INTELLECTUAL PROPERTY
Priority Data
10-2018-017259828.12.2018KR
10-2019-017655327.12.2019KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) CARRIER COMPLEX FOR EYE DROPS, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
(FR) COMPLEXE SUPPORT POUR COLLYRE, ET COMPOSITION PHARMACEUTIQUE LE CONTENANT
(KO) 점안용 담체 복합체 및 이를 포함하는 약학 조성물
Abstract
(EN)
The present invention provides a carrier composition for eye drops, and a pharmaceutical composition containing same, the carrier composition being a carrier complex, for eye drops, in which a material to be delivered is supported on a carrier, wherein the material to be delivered includes one or more selected from the group consisting of an anti-inflammatory agent, a glaucoma therapeutic agent, a calcium channel blocker (CCB), an NMDA-receptor blocker, an antioxidant, a nitric oxide synthase inhibitor, a heat shock protein (HSP), a cystinosis therapeutic agent and an antibiotic, the carrier is spherical and comprises a multilayer shell from the center of the carrier to the surface thereof, the multilayer shell comprises a core comprising a hydrogel based on a carboxymethyl cellulose (CMC) having a degree of substitution (D.S.) of 0.9, in the center of the carrier, a first shell which is located on the surface thereof and which comprises a hydrogel based on a CMC having a D.S. of 0.8, a second shell which is located on the surface thereof and which comprises a hydrogel based on a CMC having a D.S. of 0.6, and a third shell comprising a hydrogel based on a CMC having a D.S. of 0.65, and the multilayer shell comprises, on the basis of the radius of the carrier, the core having a radius of 25% length, the first shell having a thickness of 20% length, the second shell having a thickness of 40% length, and the third shell having a thickness of 15% length.
(FR)
La présente invention concerne une composition de support pour collyre, et une composition pharmaceutique la contenant, la composition de support étant un complexe support, pour collyre, dans lequel un matériau à administrer est soutenu sur un support, le matériau à administrer comprenant un ou plusieurs éléments choisis dans le groupe constitué par un agent anti-inflammatoire, un agent thérapeutique contre le glaucome, un inhibiteur calcique (CCB), un inhibiteur des récepteurs NMDA, un antioxydant, un inhibiteur de l'oxyde nitrique synthase, une protéine de choc thermique (HSP), un agent thérapeutique de la cystinose et un antibiotique, le support est sphérique et comprend une coque multicouche du centre du support à la surface de ce dernier, la coque multicouche comprend un noyau comprenant un hydrogel à base de carboxyméthylcellulose (CMC) ayant un degré de substitution (D.S.) de 0,9, au centre du support, une première coque qui est située sur la surface de ce dernier et qui comprend un hydrogel à base d'une CMC ayant un D.S. de 0,8, une deuxième coque qui est située sur la surface de cette dernière et qui comprend un hydrogel à base d'une CMC ayant un D.S. de 0,6, et une troisième coque comprenant un hydrogel à base d'une CMC ayant un D.S. de 0,65, et la coque multicouche comprenant, sur la base du rayon du support, le noyau ayant un rayon de 25 % de la longueur, la première coque ayant une épaisseur de 20 % de la longueur, la deuxième coque ayant une épaisseur de 40 % de la longueur, et la troisième coque ayant une épaisseur de 15 % de la longueur.
(KO)
본 발명은 전달 대상 물질이 담체에 담지된 점안용 담체 복합체로서, 상기 전달 대상 물질은 항염증제, 녹내장 치료제, 칼슘 채널 차단제(Calcium Channel Blocker, CCB), NMDA-수용체 차단제(NMDA-Receptor Blocker), 산화방지제(Antioxidant), 질산합성효소 억제제(Nitric Oxide Synthase Inhibitor), 열충격단백질(Heat Shock Protein, HSP), 시스틴증(Cystinosis) 치료제 및 항생제로 이루어진 군에서 선택된 하나 이상을 포함하고, 상기 담체는 구 형상을 가지고, 상기 담체는 담체의 중앙부로부터 표면까지 다층 쉘을 포함하고, 상기 다층 쉘은 담체의 중앙부에 치환도(D.S) 0.9의 CMC(Carboxy Methyl Celluose) 기반 하이드로겔을 포함하는 코어, 이의 표면에 위치하는 치환도 0.8의 CMC 기반 하이드로겔을 포함하는 제1쉘, 이의 표면에 위치하는 치환도 0.6의 CMC 기반 하이드로겔을 포함하는 제2쉘 및 치환도 0.65의 CMC 기반 하이드로겔을 포함하는 제3쉘을 포함하며, 상기 다층 쉘은, 담체의 반지름 길이를 기준으로, 25 % 길이의 반지름을 가지는 코어, 20 % 길이의 두께를 가지는 제1쉘, 40 % 길이의 두께를 가지는 제2쉘 및 15% 길이의 두께를 가지는 제3쉘을 포함하는 것을 특징으로 하는 점안용 담체 조성물 및 이를 포함하는 약학 조성물을 제공한다.
Also published as
Latest bibliographic data on file with the International Bureau